| Project/Area Number |
25462692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University (2013, 2015)
Kyorin University (2014) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HABU NOBORU 慶應義塾大学, 医学部, 助教 (60365369)
SATO YOICHIRO 慶應義塾大学, 医学部, 助教 (40624440)
WATANABE YOSHIHIRO 慶應義塾大学, 医学部, 助教 (30445374)
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| Research Collaborator |
SAKAMOTO KOJI
FUJII RYOICHI
SHIGETOMI SEIJI
OTSUKA KUNINORI
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 間葉上皮転換（MET） / 癌幹細胞 / 頭頸部扁平上皮癌 / E-cadherin / Cox2 / Flt-4 / 頸部リンパ節転移 / 多変量解析 / EMT（上皮間葉転換） / 唾液腺癌 / 転写因子 |
|---|
| Outline of Final Research Achievements |
Our study demonstrated the following results: 1) Overexpression of Cox2 and downregulation of E-cadherin were correlated with clinical malignancy of tongue squamous cell carcinoma (TSCC). Selective Cox2-inhibition in TSCC cells with low E-cadherin expression revealed anti-cancer effect via induction of MET. 2) Oct3/4 and Nanog represent probable CSC markers in head and neck SCC (HNSCC), of which upregulation may contribute to the development of delayed neck metastasis in part by enhancing cell motility and invasiveness. 3) In a subset of HNSCC cells that express Flt-4, a VEGF-C/Flt-4 autocrine mechanism regulates cell proliferation and motility by modulating expression of CNTN-1 and VEGF-C itself in tumor cells, which may contribute to cancer progression including neck lymph node metastasis.
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