| Project/Area Number |
25462727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SUZUKI TOMO 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (30613236)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Shigeru 京都府立医科大学, 医学研究科, 教授 (30116024)
YOKOI Norihiko 京都府立医科大学, 医学研究科, 准教授 (60191491)
KITAWAKI Jo 京都府立医科大学, 医学研究科, 教授 (00204925)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マイボーム腺 / 性ホルモン / マイボーム腺機能不全 / ドライアイ / 脂質分析 / 細菌 / 過酸化脂質 |
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| Outline of Final Research Achievements |
Analysis of fatty acid (FA) composition of meibum was conducted. In healthy volunteers aged 30s, women showed straight chain saturated fatty acid (SSFA) was significantly higher, mono-unsaturated fatty acid (MUFA) and poly-unsatured fatty acid (PUFA) were singificantly lower than men. In women in 60s, SSFA was significantly lower and BSFA and PUFA was higher than in 30s. In patients with meibomian gland dysfunction, SSFA was significantly higher and BSFA was significantly lower than in healthy old volunteers.
There are sex- and age- related changes in fatty acid composition of meibum which would be associated with MGD or evaporative dry eye.
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