New therapy of wet-age related macular degenaraton using ceramic microparticle with anti angiogenic drug

• Project/Area Number: 25462742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kansai Medical University
• Principal Investigator: Miki Katsuaki 関西医科大学, 医学部, 助教 (20602858)
• Co-Investigator(Kenkyū-buntansha): AIZAWA Mamoru 明治大学, 理工学部応用科学 (10255713) ; TAKAHASHI Kanji 関西医科大学, 医学部, 教授 (60216710) ; EMOTO Makoto 国際医療福祉大学, 保健医療学部, 教授 (80258540)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 加齢黄斑変性 / 血管新生 / 眼科 / ナノパーティクル / ドラックデリバリー / 病理 / 網膜

Outline of Final Research Achievements

We selected two anti-angiogenesis drug as methotrexate and cisplatin. We checked the concentration of those drug of inhibition of angiogenesis using tube formaton assay.and those drug concentration determined 5μg/ml of methotrexate and 0.5μg/ml of cisplatin. We assessed the effect of embolization by ceramic microparticle by laser induced age related macular degeneration mouse model.Ceramic microparticle tend to inhibit the area of choridal neovasularizaton comparing control. We are trying the investigation of the effect of antiangiogenic effect by ceramic microparicle with anti-angiogenic drug by laser induced age related macular degeneration mouse model.