Elucidation of neuroprotective effect of calpaan inhibitor in retina and central nerve systems in the model of glaucoma

Research Project

Project/Area Number	25462749
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Ophthalmology
Research Institution	Tohoku University
Principal Investigator	Ryu Morin 東北大学, 大学病院, 医員 (70436153)
Co-Investigator(Kenkyū-buntansha)	Moritou Satoru 福島県立医科大学, 医学部, 助教 (20647234) Nakazawa Toru 東北大学, 医学系研究科, 教授 (30361075)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	calpain / oxidative stress / retinal ganglion cells / glaucoma / retinal ganglion cell / glaucom / 緑内障 / 酸化ストレス / カルパイン
Outline of Final Research Achievements	AAPH administration was an effective model of oxidative stress-induced glaucoma, showing that oxidative stress directly activated the calpain pathway and induced RGC death in mice retina. Furthermore, inhibition of the calpain pathway protected the RGCs after AAPH administration. In our study, suppressing calpain activation reduced RGC death, suggesting that it may be a good candidate for neuroprotection therapy.

Report

(4 results)