Development of new glaucoma therapy other than decreasing intraocular pressure
| Project/Area Number |
25462750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Akita University |
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Principal Investigator |
Yoshitomi Takeshi 秋田大学, 医学(系)研究科(研究院), 教授 (60191623)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Makoto 秋田大学, 大学院医学系研究科, 准教授 (10212854)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 緑内障 / 眼循環 / 血管平滑筋 / 薬理学 / 炭酸脱水酵素阻害 / 緑内障治療薬 / 眼循環改善効果 / 視野進行 |
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| Outline of Final Research Achievements |
Topically applied carbonic anhydrase inhibitor can increase optic disc blood flow in rabbit which was assessed using laser speckle flowgraphy analyzer. Further, we investigate the direct pharmacological effect of acetazolamide and dorzolamide on isolated ciliary arterial smooth muscle. Acetazolamide had little effect compared with dorzolamide on isolated rabbit ciliary arteries in vitro using isometric tension recording method. Those results indicate that carbonic unhydrase inhibitor increase optic nerve blood flow with different pharmacological mechanisms from decreasing intraocular pressure Jpn J Ophthalmol. 2016;60:103-10）.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Dorzolamide-induced relaxation of isolated rabbit ciliary arteries mediated by inhibition of extracellular calcium influx.2016
Author(s)
Dong, Y., Sawada, Y., Cui, J., Hayakawa, M., Ogino, D., Ishikawa, M., & Yoshitomi, T.
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Journal Title
Japanese Journal of Ophthalmology
Volume: 60(2)
Issue: 2
Pages: 103-110
DOI
Related Report
Peer Reviewed / Open Access
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