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Regeneration of ocular surface fibrosis by human mesenchymal stem cell transplantation

Research Project

Project/Area Number 25462759
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionWakayama Medical University

Principal Investigator

YAMANAKA Osamu  和歌山県立医科大学, 医学部, 博士研究員 (50254545)

Co-Investigator(Kenkyū-buntansha) SAIKA Shizuya  和歌山県立医大, 医学部, 教授 (40254544)
Research Collaborator KAO Winston  シンシナティ大学, 医学部, 教授
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords創傷治癒 / 幹細胞 / 線維化 / 国際情報交換 / シグナル / サイトカイン
Outline of Final Research Achievements

We investigated the biological functions of human umbilical mesenchymal stem cells (hUMSC). hUMSC suppressed scar formation of alkali burn mouse model. Our findings showed that hUMSC mediated the activation of growth factors or cytokines such as TGFβ andTNFα to suppress fibrosis. We suggested that TNFα and βcatenin deeply associated the process of scar formation. hUMSC could be a novel alternative for treating ocular surface fibrosis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (21 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Int'l Joint Research] University of Cincinnati(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Inhibition of development of laser-induced choroidal neovascularization with suppression of infiltration of macrophages in Smad3-null mice.2016

    • Author(s)
      Iwanishi H, Fujita N, Tomoyose K, Okada Y, Yamanaka O, Flanders KC, Saika S.
    • Journal Title

      Lab Invest.

      Volume: e-journal Issue: 6 Pages: 641-51

    • DOI

      10.1038/labinvest.2016.30

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathobiology of wound healing after glaucoma filtration surgery.2015

    • Author(s)
      Yamanaka O, Kitano-Izutani A, Tomoyose K, Reinach PS.
    • Journal Title

      BMC Ophthalmol.

      Volume: 15 Issue: S1 Pages: 157-157

    • DOI

      10.1186/s12886-015-0134-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea.2015

    • Author(s)
      Tomoyose K, Okada Y, Sumioka T, Miyajima M, Flanders KC, Shirai K, Morii T, Reinach PS, Yamanaka O, Saika S.
    • Journal Title

      J Ophthalmol.

      Volume: Sep 27 Pages: 706404-706404

    • DOI

      10.1155/2015/706404

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histological analysis of a cornea following experimental femtosecond laser ablation.2014

    • Author(s)
      Sumioka T, Miyamoto T, Takatsuki R, Okada Y, Yamanaka O, Saika S.
    • Journal Title

      Cornea.

      Volume: 33 Issue: Supplement 11 Pages: 19-24

    • DOI

      10.1097/ico.0000000000000251

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of the loss of conjunctival Muc16 on corneal epithelium and stroma in mice.2014

    • Author(s)
      Shirai K, Okada Y, Cheon DJ, Miyajima M, Behringer RR, Yamanaka O, Saika S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 6 Pages: 3626-3637

    • DOI

      10.1167/iovs.13-12955

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impairment of corneal epithelial wound healing in a TRPV1-deficient mouse.2014

    • Author(s)
      Sumioka T, Okada Y, Reinach PS, Shirai K, Miyajima M, Yamanaka O, Saika S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 5 Pages: 3295-3302

    • DOI

      10.1167/iovs.13-13077

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 組織修復におけるmatricellular proteinの役割2014

    • Author(s)
      山中 修 雑賀司珠也
    • Journal Title

      医学の歩み

      Volume: 248 Pages: 515-522

    • Related Report
      2013 Research-status Report
  • [Journal Article] Lumican Binds ALK5 to Promote Epithelium Wound Healing2013

    • Author(s)
      Osamu Yamanaka, Yong Yuan, Vivien Jane Coulson-Thomas, Tarsis Ferreira Gesteira, Mindy K. Call, Yujin Zhang, Jianhua Zhang, Shao-Hsuan Chang, Changchun Xie, Chia-Yang Liu, Shizuya Saika, James V. Jester, Winston W-Y Kao
    • Journal Title

      PLOS one

      Volume: 8 Issue: 12 Pages: e82730-e82730

    • DOI

      10.1371/journal.pone.0082730

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased fragility, impaired differentiation, and acceleration of migration of corneal epithelium of epiplakin-null mice.2013

    • Author(s)
      Kokado M, Okada Y, Goto M, Ishikawa K, Miyamoto T, Yamanaka O, Fujiwara S, Saika S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 54 Issue: 5 Pages: 3780-9

    • DOI

      10.1167/iovs.12-11077

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] modulation of wound healing response in the corneal stroma by osteopontin and tenascin-C.2013

    • Author(s)
      Saika S, Sumioka T, Okada Y, Yamanaka O, Kitano A, Miyamoto T, Shirai K, Kokado H.
    • Journal Title

      Ocul Surf.

      Volume: 11 Issue: 1 Pages: 12-15

    • DOI

      10.1016/j.jtos.2012.09.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired cornea wound healing in a tenascin C-deficient mouse model.2013

    • Author(s)
      Sumioka T, Kitano A, Flanders KC, Okada Y, Yamanaka O, Fujita N, Iwanishi H, Kao WW, Saika S.
    • Journal Title

      Lab Invest.

      Volume: 93 Pages: 207-217

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] EDMT and matricellular protein2016

    • Author(s)
      Osamu Yamanaka
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-04-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 結膜創傷治癒過程でのTGFβ/β-cateninクロスオーバー2015

    • Author(s)
      山中 修 友寄勝夫 雑賀司珠也
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 培養ヒト結膜線維芽細胞でのTGFb/bcateninクロスオーバー2014

    • Author(s)
      山中 修  友寄勝夫 Winston WY Kao 雑賀司珠也
    • Organizer
      日本緑内障学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of β-catenin inhibitor, ICG-001, on cultured human conjunctival fibroblast2014

    • Author(s)
      Osamu Yamanaka, Winston WY Kao, Shizuya Saika
    • Organizer
      The Association for Research in vision and Ophthalmology
    • Place of Presentation
      Florida, USA
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] β-catenin阻害の培養結膜線維芽細胞に対する影響2014

    • Author(s)
      山中 修 雑賀司珠也
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Loss of TNFα accelerates inflammatory fibrosis during wound healing in conjunctiva in mice.2014

    • Author(s)
      Osamu Yamanaka
    • Organizer
      Gordon research conference
    • Place of Presentation
      Bentura USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Endogenous TNFα is required for normal tissue repair in mouse conjunctiva2013

    • Author(s)
      Osamu Yamanaka, Ai Kitano, Yuka Okada, Winston W-Y Kao, Shizuya Saika
    • Organizer
      ARVO
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 結膜創傷治癒におけるTNFαの役割2013

    • Author(s)
      山中 修 泉谷 愛 岡田由香 Winston Kao 雑賀司珠也
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] ルミカンの創傷治癒における機序と可能性2013

    • Author(s)
      山中 修
    • Organizer
      日本結合組織学会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2022-01-27  

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