Regeneration of ocular surface fibrosis by human mesenchymal stem cell transplantation
| Project/Area Number |
25462759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
YAMANAKA Osamu 和歌山県立医科大学, 医学部, 博士研究員 (50254545)
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| Co-Investigator(Kenkyū-buntansha) |
SAIKA Shizuya 和歌山県立医大, 医学部, 教授 (40254544)
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| Research Collaborator |
KAO Winston シンシナティ大学, 医学部, 教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 創傷治癒 / 幹細胞 / 線維化 / 国際情報交換 / シグナル / サイトカイン |
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| Outline of Final Research Achievements |
We investigated the biological functions of human umbilical mesenchymal stem cells (hUMSC). hUMSC suppressed scar formation of alkali burn mouse model. Our findings showed that hUMSC mediated the activation of growth factors or cytokines such as TGFβ andTNFα to suppress fibrosis. We suggested that TNFα and βcatenin deeply associated the process of scar formation. hUMSC could be a novel alternative for treating ocular surface fibrosis.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Lumican Binds ALK5 to Promote Epithelium Wound Healing2013
Author(s)
Osamu Yamanaka, Yong Yuan, Vivien Jane Coulson-Thomas, Tarsis Ferreira Gesteira, Mindy K. Call, Yujin Zhang, Jianhua Zhang, Shao-Hsuan Chang, Changchun Xie, Chia-Yang Liu, Shizuya Saika, James V. Jester, Winston W-Y Kao
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Journal Title
DOI
Related Report
Peer Reviewed
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