| Project/Area Number |
25462782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Sadashige Uemura 川崎医科大学, 医学部, 教授 (40160220)
Hisako Kuyama 川崎医科大学, 医学部, 講師 (90548645)
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| Co-Investigator(Renkei-kenkyūsha) |
Shigenobu Tone 川崎医科大学, 医学部, 准教授 (70211399)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医療 / 腸管分化誘導 / iPS細胞 / 胚様体 / 人工腸管 / iPS cell / tissue engineering / smooth muscle / gut / activin A / short bowel syndrome |
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| Outline of Final Research Achievements |
As an initial research toward making artificial gut, we have inducted a gut like structure using tissue engineering technique in vitro. Thanks to this fund, we could brush up the induction technique, but the regeneration efficiency of the gut like structure is still low in spite of an innovation of additional culture medium and growth factors. It may be possible to extend the application of this technique to the gut like structure over clinical intestinal incompetence in the future.
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