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The effect of ischemia and reperfusion injury on the endothelial cells

Research Project

Project/Area Number 25462819
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Obata Yukako  浜松医科大学, 医学部附属病院, 助教 (90432210)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords虚血再灌流 / 低酸素 / 血管内皮 / エネルギー枯渇
Outline of Final Research Achievements

Endothelial cells play important roles such as organs during inflammation and ischemia and reperfusion injury and it has been known that they work as mediator. We measured the intracellular Ca2+ concentration of porcine aortic endothelial cells as endothelial function, when the energy depletion by chemical agents and the energy supply with medium was caused on the cells.
We found that the bradykinin-induced Ca2+ response and the thapsigargin-induced Ca2+ response partly suppressed after the energy depletion with KCN and 2-Deoxy-D-glucose and the energy supply with medium. These findings suggest that endothelial function was altered, at least in part, by the energy depletion and that the change of endothelial function occurs in the clinical hypoxia and reperfusion.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 代謝阻害剤を用いた細胞内エネルギー枯渇と再供給が血管内皮細胞機能に及ぼす影響2016

    • Author(s)
      小幡由佳子
    • Organizer
      第43回日本集中治療医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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