Predictive value of serum NGAL for the neurological outcome of post cardiac arrest victims

Research Project

Project/Area Number	25462824
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Emergency medicine
Research Institution	Kumamoto University
Principal Investigator	KASAOKA SHUNJI 熊本大学, 医学部附属病院, 教授 (90243667)
Co-Investigator(Kenkyū-buntansha)	FUJITA Motoki 山口大学, 大学院医学系研究科, 助教 (50380001)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	心停止後症候群 / バイオマーカー / 予後予測
Outline of Final Research Achievements	In this study, we measured serum NGAL in post cardiac arrest syndrome (PCAS) patients to investigate the predictive value of neurological outcome. Serum NGAL showed significant difference in day 2 (G: 282±116 ng/mL v.s. P: 299±87 ng/mL in day1: P = 0.609, G: 185±124 ng/mL v.s. P: 353±110 ng/mL in day 2: P<0.001). The ROC curve analysis showed area under the curve of NGAL in day 2 was 0.871, and the area of NSE in day2 showed 0.918. Serum NGAL in PCAS patients had the predictive value for neurological outcome which is comparable to serum NSE.