Integrated analysis of endocan as a new sepsis biomarker
| Project/Area Number |
25462833
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | endocan / バイオマーカー / 菌血症 / 敗血症 / 血流感染症 |
|---|
| Outline of Final Research Achievements |
Endocan is a newly recognized biomarker of sepsis. However, there have been no studies of the trends in endocan levels during infection and their associations with other clinical factors. The aim of this study was to assess the time course of endocan levels and the associations of endocan with clinical factors during infection by comparison with other biomarkers.Serum samples and blood cultures were obtained from patients who were diagnosed with infection. Serum endocan, C-reactive protein (CRP), and procalcitonin (PCT) levels during infection were measured.
Endocan levels at day 0 in patients with bacteremia were higher than those without bacteremia, but neither CRP levels nor PCT levels. Areas under the receiver operator characteristic curves of endocan were 0.662. In bacteremic cases, serum endocan levels in bacteremia tended to be higher than in non-bacteremic cases.
|
Report
(4 results)
Research Products
(15 results)
