The effect of soft tissue injury on mesenteric lymph bioactivity and organ injury following hemorrhagic shock

• Project/Area Number: 25462838
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nippon Medical School
• Principal Investigator: masuno tomohiko 日本医科大学, 医学部, 講師 (00318528)
• Co-Investigator(Kenkyū-buntansha): Yokota Hiroyuki 日本医大学, 医学系研究科, 教授 (60182698) ; Arai Masatoku 日本医科大学, 医学部, 助教 (60267127) ; Tsukamoto Takeshi 日本医科大学, 医学部, 助教 (20626270)
• Research Collaborator: Sakamoto Wakako
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 出血性ショック / 組織損傷 / 腸管リンパ液 / 臓器障害

Outline of Final Research Achievements

We have shown that mesenteric hypoperfusion due to circulatory shock elaborates bioactive agents in mesenteric lymph which result in subsequent distant organ injury. Severe traumatic shock cases usually involve soft tissue injury. The purpose of this study was to investigate the effect of soft tissue injury on mesenteric lymph bioactivity and organ injury. Homogenized tissue matrix transplantation increased mesenteric lymph bioactivity.

Research Products

• [Presentation] Comprehensive analysis of microRNA profiles in normal rodent mesenteric lymph (2015)
  • Author(s): 1.Sakamoto W, Masuno T, Tsukamoto T,et.al.
  • Organizer: 38th Annual conference on Shock
  • Place of Presentation: Denver, USA
  • Year and Date: 2015-06-06
  • Int'l Joint Research