| Project/Area Number |
25462846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SUZUKI Yuko 北海道大学, 遺伝子病制御研究所, 学術研究員 (90646118)
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| Co-Investigator(Kenkyū-buntansha) |
OHGA Noritaka 北海道大学, 大学院歯学研究科, 助教 (40548202)
AKIYAMA Kosuke 北海道大学, 遺伝子病制御研究所, 客員研究員 (10609100)
MAISHI Nako 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腫瘍血管 / 薬剤抵抗性 / トランスポーター / がん幹細胞 |
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| Outline of Final Research Achievements |
We have reported that drug resistance-related gene, P-glycoprotein (P-gp) is upregulated in tumor endothelial cells (TECs). In this study, we examined the involvement of P-gp expression of TEC in cancer refractory. When TECs were treated with both paclitaxel and P-gp inhibitor, TEC proliferation was inhibited compared to paclitaxel alone group. Combination treatment with paclitaxel and P-gp inhibitor abrogated TEC resistance in mouse tumor model. These results suggested that inhibiting P-gp in TECs may be a good strategy for cancer therapy.
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