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Involvement of microenvironment with cancer/epithelial stem cell in oral lesions

Research Project

Project/Area Number 25462864
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionNagasaki University

Principal Investigator

FUJITA Shuichi  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (00181355)

Co-Investigator(Renkei-kenkyūsha) YAMADA Shin-ichi  信州大学, 大学院医学系研究科, 准教授 (50380853)
IKEDA Tohru  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (00211029)
SHIBATA Yasuaki  長崎大学, 医歯薬学総合研究科(医学系), 講師 (80253673)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords微小環境 / 扁平上皮癌 / リンパ節転移 / 癌関連マクロファージ / 癌関連好中球 / 癌関連線維芽細胞 / CCL2 / CCR2 / marginal histiocytosis / CAF / 口腔扁平上皮癌 / 転移 / 腫瘍関連好中球 / 腫瘍関連マクロファージ / CCL2-CCR2 pathway / 癌幹細胞 / CD204
Outline of Final Research Achievements

Oral squamous cell carcinoma (SCC) often metastasizes to cervical lymph nodes. We immunohistochemically examined the involvement of CCL2-CCR2 axis with construction of microenvironment suitable for metastasis in lymph nodes.Marginal sinus histiocytosis was frequently observed in metastatic cases. CCL2 was expressed in tumor-associated neutrophils (TANs) and moderately or poorly differentiated SCC was detected at primary tumor sites. TANs expressing CCL2 flowed into the marginal sinus in the lymph nodes. CCR2-positive macrophages and mesenchymal cells infiltrated the tumor stroma and were seen within the carcinoma nests. They were predominantly present in the marginal sinus of metastatic cases. In small metastatic foci, alpha-SMA-positive spindle cells resembling carcinoma-associated fibroblasts (CAFs) were observed adjacent to the macrophages. The results indicate that the CCL2-CCR2 axis is associated with lymphatic metastasis from oral squamous cell carcinoma.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2017 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] The CCL2-CCR2 Axis in Lymph Node Metastasis From Oral Squamous Cell Carcinoma: An Immunohistochemical Study2017

    • Author(s)
      Fujita S, Ikeda T
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 75 Issue: 4 Pages: 742-749

    • DOI

      10.1016/j.joms.2016.09.052

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 口腔扁平上皮癌の頸部リンパ節転移における腫瘍関連マクロファージとCCR2陽性細胞の役割2015

    • Author(s)
      1.藤田修一、池田 通
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔扁平上皮癌の頸部リンパ節転移における腫瘍関連マクロファージとCCR2陽性細胞の役割2015

    • Author(s)
      藤田修一、池田通
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-05-01
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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