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Effect of estrogen on GABAergic inhibition of orofacial pain in female rats

Research Project

Project/Area Number 25462908
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionNational Defense Medical College

Principal Investigator

TASHIRO AKIMASA  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (60598118)

Research Collaborator Bereiter David A  ミネソタ大学, 教授
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords痛覚 / エストロゲン / GABA / mGluR / 顎関節 / オピオイド / 顎関節痛 / 代謝型グルタミン酸受容体 / 三叉神経
Outline of Final Research Achievements

Arthritis and musculoskeletal disorders, including temporomandibular joint disorder (TMD), are chronic pain conditions that occur more frequently in women of reproductive age than men. However, considerable evidence suggests that estrogen (E2) status plays a significant role. Although E2 acts GABAergic neurons to affect a wide range of functional pathways in the CNS, it is not known if E2 interact GABAergic activity in the brain regions that process nociceptive input from the TMJ. Recent studies indicated that E2-induced IPSC suppression depends on ERa- and mGluR1-dependent mobilization to decrease the probability of GABA release from inhibitory synaptic inputs. In present study we demonstrated that 1) E2 suppressed GABA(A) mediated inhibition 2)E2 acts mGluR1 dependent mechanism to enhance TMJ nociceptive processing by laminae I-II neurons in the medullary dorsal horn.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Local group I mGluR1 antagonist reduces TMJ-evoked activity of trigeminal subnucleus caudalis neurons in female rats.2015

    • Author(s)
      Tashiro A, Nishida Y , Bereiter DA
    • Journal Title

      Neuroscience

      Volume: 299 Pages: 125-133

    • DOI

      10.1016/j.neuroscience.2015.04.051

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status2014

    • Author(s)
      Tashiro A, et al
    • Journal Title

      Neuroscience

      Volume: 259 Pages: 53-62

    • DOI

      10.1016/j.neuroscience.2013.11.053

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 光刺激が三叉神経を興奮させるメカニズム2016

    • Author(s)
      岡本圭一郎、田代晃正、黒瀬雅之、山村健介、 Breiter David
    • Organizer
      第93回日本生理学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Local KOR agonist reduces TMJ-evoked activity of trigeminal subnucleus caudalis neurons in an estrogen-dependent manner2015

    • Author(s)
      Tashiro A and Nishida Y
    • Organizer
      Society for Neuroscience 2015
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] κ受容体を介した三叉神経脊髄路核尾側亜核のニューロン活動の変調に対するエストロゲンの影響2015

    • Author(s)
      田代晃正、西田育弘
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of estrogen on Mu and Kappa opioid inhibition of TMJ-responsive neurons in superficial laminae at the spinomedullary junction in ovariectomized female rats2015

    • Author(s)
      Tashiro A and Nishida Y
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Kappa opioid receptor-mediated antinociception of temporomandibular joint -responsive neurons in superficial laminae at spinomedullary junction in female rats depends on estrogen status.2014

    • Author(s)
      Tashiro A and Nishida Y
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] エストロゲンが痛みの制御に与える影響2014

    • Author(s)
      田代晃正
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of sex steroid hormone on kappa opioid receptor-mediated antinociception of TMJ-responsive neurons in superficial laminae at spinomedullary junction of ovariectomized female rats2014

    • Author(s)
      Tashiro A, et al.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 三叉神経脊髄路核ニューロンの興奮が光刺激により誘発される眼球内血流量変化に及ぼす影響2014

    • Author(s)
      田代晃正 他
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
  • [Presentation] Estrogen acts through mGluR1 to modulate TMJ-evoked activity of trigeminal subnucleus caudalis neurons in female rats2013

    • Author(s)
      Tashiro A, et al.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Estrogen acts through mGluR1 to modulate TMJ-evoked activity of trigeminal subnucleus caudalis neurons in female rats2013

    • Author(s)
      Tashiro A, Nishida Y
    • Organizer
      Society for Neuroscience 2013
    • Place of Presentation
      San Diego in USA
    • Related Report
      2013 Research-status Report
  • [Book] 口腔顔面痛の診断と治療ガイドブック2013

    • Author(s)
      編者 日本口腔顔面痛学会
    • Total Pages
      229
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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