Elucidate the mechanism of aggravation of endodontic disease on diabetic patients

• Project/Area Number: 25462960
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Uchida Yushi 広島大学, 医歯薬保健学研究院, 助教 (40363080)
• Co-Investigator(Kenkyū-buntansha): OUHARA Kazuhisa 広島大学, 大学院医歯薬保健学研究院, 助教 (80550425)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病 / 歯内疾患 / 好中球 / RAGE / 歯髄由来繊維芽細胞 / 歯内病変 / 歯髄炎 / 根尖性歯周炎 / 糖最終産物の受容体

Outline of Final Research Achievements

Diabetes Mellitus (DM) effects on endodontic disease as other disease. Endodontic disease of DM model mouse proceeds more rapidly than normal mouse. The white blood cell which circulated through the whole body change the some functions, and the inflammation of endodontic tissue proceed rapidly. But the fibroblasts from pulp tissue on DM patients produce the receptor for advanced glycation endproducts (RAGE) as much as healthy subjects. It might be very important that RAGE on the white blood cell more than cell of endodontic tissue.

Research Products

• [Presentation] A Role of Receptor for Advanced Glycation Endproducts (2015)
  • Author(s): 内田雄士
  • Organizer: 国際歯科研究学会
  • Place of Presentation: ボストン（米国）
  • Year and Date: 2015-03-11 – 2015-03-14