Study of the effects of serine proteases on the cariogenicity of Streptococcus mutans
| Project/Area Number |
25462962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OZAKI Kazumi 徳島大学, 大学院医歯薬学研究部, 教授 (90214121)
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| Co-Investigator(Kenkyū-buntansha) |
YUMOTO Hiromichi 徳島大学, 病院, 講師 (60284303)
HOSOKAWA Yoshitaka 徳島大学, 大学院医歯薬学研究部, 助教 (90346601)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バイオフィルム / クオラムセンシング / オートインデューサー |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate the effect of the enzymes, which digest autoinducers, on the cariogenicity of Streptococcus mutans. Trypsin and rHtrA were tended to inhibit bacterial growth and the adherence of S.mutans to a glass test tube, furthermore, suppress biosynthesis of intra/extra-cellular polysaccharide in comparison with negative control. These results suggested that these enzymes will be able to exhibit antibacterial activities and inhibit biofilm formation by S.mutans.
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Report
(4 results)
Research Products
(19 results)
