| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The aim of this study is establishment of the therapy that makes a biological direct pulp capping. At first, we identified the crucial role of the heat shock protein (HSP) 70 to protect against various stimulus in cells derived from pulp and this results suggests the possibility of HSP70 inducer for direct pulp capping. Next, we investigated inflammatory response mechanism of pulp cells and potential of novel anti-inflammatory agent for pulp cells. Furthermore, we evaluated several methods to induce regenerated dentin formation with proper quality and quantity. We found that platelet-rich plasma and bioactive glass enhance hard tissue formation as well as differentiation of odontoblastic cells.
As mentioned above, we obtained evidence about the capability of the biological pulp capping method in a series of the studies.
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