Establishment of biological direct pulp capping method with the agent inducing HSPs
| Project/Area Number |
25462979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 直接覆髄 / heat shock protein / 歯髄 / 炎症 / 象牙質形成 / 覆髄 / 象牙質－歯髄複合体 / 分化誘導 / 石灰化能 / 耐性 / 熱ショックタンパク質 / 細胞周期 / 炎症応答 / 象牙芽細胞 / 象牙質ー歯髄複合体 / 熱ショックタンパク / 生体活性ガラス |
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| Outline of Final Research Achievements |
The aim of this study is establishment of the therapy that makes a biological direct pulp capping. At first, we identified the crucial role of the heat shock protein (HSP) 70 to protect against various stimulus in cells derived from pulp and this results suggests the possibility of HSP70 inducer for direct pulp capping. Next, we investigated inflammatory response mechanism of pulp cells and potential of novel anti-inflammatory agent for pulp cells. Furthermore, we evaluated several methods to induce regenerated dentin formation with proper quality and quantity. We found that platelet-rich plasma and bioactive glass enhance hard tissue formation as well as differentiation of odontoblastic cells.
As mentioned above, we obtained evidence about the capability of the biological pulp capping method in a series of the studies.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] The p65 subunit of NF-κB suppresses BMP2-induced bone formation by inhibiting Smad DNA binding via an interaction with Smad42014
Author(s)
Hirata-Tsuchiya S, Fukushima H, Katagiri T, Ohte S, Shin M, Nagano K, Aoki K, Morotomi T, Sugiyama G, Doi T, Takeuchi H, Ohya K, Terashita M, Hirata M, Kitamura C, Jimi E.
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Journal Title
Mol Endocrinol
Volume: 28
Issue: 9
Pages: 1460-1470
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] シナリオベース実習を用いた体験先導型臨床基礎教育の教育効果2015
Author(s)
諸冨孝彦，西藤法子，吉居慎二，平田－土屋志津，鷲尾絢子，市丸－末松美希, 中川愛加，中山皓平，大塚麻衣，藤元政考，松山篤史，浦田真梨子，花田可緒理，宮原宏武，北村知昭
Organizer
第143回日本歯科保存学会2015年度秋季学術大会
Place of Presentation
東京都
Year and Date
2015-11-12
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