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Development of noninvasive in vivo hard tissue imaging system using photoacoustic microscope

Research Project

Project/Area Number 25462982
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

Hatori Kouki  東北大学, 歯学研究科(研究院), 助教 (40372320)

Co-Investigator(Kenkyū-buntansha) SAIJO Yoshifumi  東北大学, 大学院医工学研究科, 教授 (00292277)
SASAKI Keiichi  東北大学, 大学院歯学研究科, 教授 (30178644)
HAGIWARA Yoshihiro  東北大学, 大学院医学系研究科, 准教授 (90436139)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords光音響顕微鏡 / 光音響効果 / 硬組織イメージング / 非侵襲 / in vivo / 血液循環 / 組織弾性 / 光音響信号 / 赤血球 / 片側性咬合支持 / 咬筋 / 超音波信号 / イメージング装置 / 片側咬合支持 / 下顎頭軟骨 / 線維層 / 軟骨下骨 / ラット / 顎関節症 / 下顎頭
Outline of Final Research Achievements

Male Wistar rats of 20-week-old (n=5) were used in this study. Mandibles were resected and fixed. Mandibular condylar cartilage was observed with photoacoustic microscopy (PAS). PAS visualized the lesion from subchondral bone to cancellous bone. Ultrasound microscopy visualized the whole cartilage lesion. Thus PAS could visualized the 3-dimentional color image of from cartilage to cancellous bone.
Male Wistar rats of 16-week-old (n=5) were used in this study. Right three molars of maxilla were extracted. After 4 weeks of extraction, both masseter muscles were resected and fixed. Masseter muscle was observed with PAS. Photoacoustic signal was lower in extracted side than in non-extracted side. Ultrasound signal was higher in non^extracted side than in non-extracted side.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Acoustic Impedance Microscope for Imaging Human Carious Dentin2015

    • Author(s)
      K. Hatori, Y. Naganuma, Y. Saijo, Y. Hagiwara, M. Iikubo, K. Igari, K. Sasaki
    • Journal Title

      12th Western Pacific Acoustics Conference 2015

      Volume: 1 Pages: 1-4

    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Acoustic diagnosis device for dentistry2016

    • Author(s)
      Kouki Hatori
    • Organizer
      Innovative Research for Biosis-Abiosis Intelligent Interface Symposium The 6th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Gonryo Kaikan, Sendai, Japan
    • Year and Date
      2016-01-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Acoustic Impedance Microscope for Imaging Human Carious Dentin2015

    • Author(s)
      K. Hatori, Y. Naganuma, Y. Saijo, Y. Hagiwara, M. Iikubo, K. Igari, K. Sasaki
    • Organizer
      12th Western Pacific Acoustics Conference 2015
    • Place of Presentation
      Grand Copthorne Waterfront Hotel, Singapore
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 光音響超音波顕微鏡を利用した片側咬合支持モデルラットにおける咬筋の経時的変化2015

    • Author(s)
      羽鳥弘毅、西條芳文、飯久保正弘、萩原嘉廣、佐々木啓一
    • Organizer
      公益社団法人日本補綴歯科学会東北・北海道支部総会・学術大会
    • Place of Presentation
      岩手県歯科医師会館8020プラザ
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 光音響顕微鏡によるラット咬筋の評価2014

    • Author(s)
      山崎玲奈,羽鳥弘毅,飯久保正弘,萩原嘉廣,佐々木啓一,西條芳文
    • Organizer
      第48回日本生体医工学会東北支部大会
    • Place of Presentation
      東北大学工学部青葉記念会館(宮城)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] The Application of Ultrasound Microscope for Human Caries Dentin2014

    • Author(s)
      K. HATORI, Y. NAGANUMA, Y. SAIJO, Y. HAGIWARA, Y. SHIMIZU, K. IGARI, K. SASAKI
    • Organizer
      The 62nd Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      KKR HOTEL OSAKA, (大阪)
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Ultrasound Microscope for Investigation of Elasticity of Human Carious Dentin2014

    • Author(s)
      Hatori K, Naganuma Y, Saijo Y, Hagiwara Y, Shimizu Y, Igari K, Sasaki K
    • Organizer
      INDONESIAN PROSTHODONTIC SOCIETY and JAPAN PROSTHODONTIC SOCIETY JOINT MEETING
    • Place of Presentation
      Grand Nikko, Nusa Dua, Bali, (Indonesia)
    • Year and Date
      2014-10-30 – 2014-11-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 光音響イメージングを利用したラット下顎頭の可視化2014

    • Author(s)
      羽鳥弘毅、佐藤みか、西條芳文、萩原嘉廣、冨士岳志、髙橋健太、佐々木啓一
    • Organizer
      平成25年度第4回光超音波画像研究会
    • Place of Presentation
      産業技術総合研究所つくば東事業所第1会議室(つくば市、茨城県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Ultrasound Microscopic Imaging of Human Caries Dentin2014

    • Author(s)
      Yukihiro Naganuma, Kouki Hatori, Yoshifumi Saijo, Yoshihiro Hagiwara, Yoshinaka Shimizu, Kazuko Igari, Keiichi Sasaki
    • Organizer
      East Asisn Consortium on Biomedical Engineering 8th Student Workshop
    • Place of Presentation
      Aoba Memorial Hall, Aobayama Campus, Tohoku University, Sendai, Japan
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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