Studies on the novel stress response through galectin -1
| Project/Area Number |
25463010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Maebashi Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAGURI KENICHI 神奈川歯科大学, 歯学部, 講師 (10235286)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 拘束ストレス / ガレクチン-1 / 脾臓 / 胸腺 / すい臓 / 膵臓 / リンパ球 / CD45 / ストレス / 免疫組織化学 / CD45+リンパ球 |
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| Outline of Final Research Achievements |
We demonstrated that restraint stress markedly and rapidly induces the blood level of Galectin-1 (Gal-1). In this study, we revealed that Gal-1 levels in the spleen and thymus increased after the restraint stress. Immunohistochemical analysis showed that immunoreactivity for Gal-1 was detected in the periarterial lymphatic sheath (PALS) of the spleen and in the medulla of the thymus and the staining intensity increased after restraint stress. The Gal-1 co-localized with CD45+ lymphocytes in the PALS and the medulla. These results suggested that stress-induced Gal-1 in blood may modulate the immune response through apoptosis by binding to CD45+ lymphocytes. Furthermore, Gal-1 levels in the pancreas also increased after the restraint stress and the immunoreactive cells were corresponded to fibroblasts and smooth muscle cells of blood capillary located pancreatic interlobullus. Gal-1 may participate in one of pancreatic responses against stress.
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Report
(4 results)
Research Products
(3 results)
