Development of novel therapy for type 2 diabetes induced xerostomia
| Project/Area Number |
25463011
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Prosthodontics/ Dental materials science and
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
Kondo Yusuke 九州歯科大学, 歯学部, 助教 (00611287)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MUKAIBO TARO 九州歯科大学, 歯学部, 助教 (50635117)
HOSOKAWA RYUJI 九州歯科大学, 歯学部, 教授 (60211546)
MASAKI CHIHIRO 九州歯科大学, 歯学部, 准教授 (60397940)
中本 哲自 松本歯科大学, 歯学部, 教授 (30514989)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 口腔乾燥症 / 糖尿病 / 唾液腺 / 歯学 / 2型糖尿病 |
|---|
| Outline of Final Research Achievements |
Xerostomia has been reported to be closely associated with diabetes. We have analyzed salivary gland function in KK-Ay, a diabetes mouse model, to explore how diabetes induces xerostomia.
Ca+ release from endoplasmic reticulum was significantly less in KK-Ay than control, which might result in decreased salivary secretion from KK-Ay submandibular gland. result in a decreased concentrations of Na+ and Cl- in the secreted saliva.
|
Report
(4 results)
Research Products
(2 results)
