Development of micro/nano-patterned sheet for periodontal tissue regeneration aimed at 3d tissue construction
| Project/Area Number |
25463047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マイクロ・ナノパターン / ナノインプリント / ゼラチン / アパタイト / コンポジットレジン / 歯周組織再生 / 歯根膜線維芽細胞 / 骨芽細胞様細胞 / 破骨細胞 / 微細構造 / コラーゲン / 歯科材料 / パターニング / 歯根膜再生 / 細胞応答 |
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| Outline of Final Research Achievements |
Preparation of micro/nano-patterned sheets was investigated by nanoimprinting with collagen or apatite materials for periodontal tissue regeneration. Micro/nano patterned gelation can be obtained by thermal crosslinking or crosslinking with genipin. The apatite or composite resin patterns were obtained by using appropriate materials and molds. As a result of cell assay, the patterns largely influenced cell adhesion, proliferation, and alignment.
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Report
(6 results)
Research Products
(34 results)
