Pioneering research of the effect of Bisphosphonate to achieved osseointegrated implants

• Project/Area Number: 25463049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka University
• Principal Investigator: WADA MASAHIRO 大阪大学, 歯学部附属病院, 講師 (20452451)
• Co-Investigator(Kenkyū-buntansha): OKUNO IKUHISA 大阪大学, 歯学研究科, 招へい教員 (30362677)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ビスフォスフォネート / オッセオインテグレーション / インプラント周囲炎

Outline of Final Research Achievements

We examined the medium-and-long term influence of Bisphosphonate (BP) on implant integration rat model. In addition, we applied bacterial biofilm around the implant which got osseointegration artificially and examined the effect of BP. As a result, the meaningful difference was not recognized in various comparisons biomakers as well as the dosage for a short term. In addition, we did not recognize the meaningful difference even if we put biofilm and did not show the loss of the osseointegration or MRONJ.

Research Products

• [Journal Article] Can we predict the initial torque using the bone density around the implant? (2016)
  • Author(s): M Wada, T Suganami, M Sogo, Y Maeda
  • Journal Title: International journal of Oral and maxillofacial surgery Volume: Feb;45(2) Pages: 221-5
  • Peer Reviewed