The role of CCR10+ regulatory T cells in oral squamous cell carcinoma.

• Project/Area Number: 25463078
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: WATANABE YOSHIKO 浜松医科大学, 医学部, 助教 (10444358)
• Co-Investigator(Kenkyū-buntansha): 加藤 文度 浜松医科大学, 医学部, 教授 (60204492)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔扁平上皮癌 / 免疫担当細胞 / 口腔癌 / リンパ球 / ケモカイン

Outline of Final Research Achievements

We examined the infiltration of regulatory T cells in the oral squamous cell carcinoma.CCR10+ regulatory T cells infiltrated to the cancer stroma. We suggested that tumor cells or peritumoral tissue induced CCR10+ regulatory T cells and got immunotolerance in oral squamous cell carcinoma.