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Development of novel treatment and functional analysis of molecular regulation of Sjogren's syndrome by using mesenchymal stem cells

Research Project

Project/Area Number 25463084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

ITO Satoshi  岡山大学, 歯学部, 博士研究員 (00319972)

Co-Investigator(Kenkyū-buntansha) NAGATSUKA Hitoshi  岡山大学, 大学院医歯(薬)学総合研究科, 教授 (70237535)
TSUJIGIWA Hidetsugu  岡山理科大学, 理学部, 教授 (70335628)
TAMAMURA Ryo  日本大学, 歯学部, 助教 (00403494)
KATASE Naoki  川崎医科大学, 医学部, 助教 (30566071)
MIZUKAWA Nobuyoshi  岡山大学, 大学病院, 講師 (00263608)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsシェーグレン症候群 / 骨髄細胞 / 唾液腺 / 唾液線
Outline of Final Research Achievements

In this study, we tried to development the treatment of Sjogren's syndrome by using mesenchymal stem cells. When we used the mouse that was implanted GFP positive bone marrow cells, GFP positive cells was observed in salivary gland. And GFP positive cells were shown in mucous cells, myoepithelial cells, salivary duct and the specific protein in the salivary gland. In addition, when we implanted the GFP positive bone marrow cells to Sjogren's syndrome model mice, the salivary gland body reduced obviously. Therefore these findings indicate that bone marrow cells affect the restoration of salivary gland, and that anti-inflammatory effect of bone marrow cells treat Sjogren's syndrome.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Pathological Analysis of Cell Differentiation in Cholesterol Granulomas Experimentally Induced in Mice.2016

    • Author(s)
      Sakai K, Nakano K, Matsuda S, Tsujigiwa H, Ochiai T, Shoumura M, Osuga N, Hasegawa H, Kawakami T.
    • Journal Title

      Int J Med Sci

      Volume: 13(3) Issue: 3 Pages: 220-224

    • DOI

      10.7150/ijms.13853

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Ability of Transplanted Bone Marrow-Derived Cells to Differentiate into Parenchymal Cells of Salivary Glands2013

    • Author(s)
      Yuan Y-W, Tamamura R, Lei L, Katase N, Ara S G, Ito S, Tsujigiwa H, Nagatsuka H
    • Journal Title

      J Hard Tissue Biology

      Volume: 22(4) Pages: 433-438

    • NAID

      130004480613

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Promotion of Transplanted Bone Marrow-derived Cell Migration into the Periodontal Tissues due to Orthodontic Mechanical Stress2013

    • Author(s)
      Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nakamura T, Okafuji N, Nagatsuka H, Kawakami T
    • Journal Title

      Int J Med Sci

      Volume: 10(10) Issue: 10 Pages: 1321-1326

    • DOI

      10.7150/ijms.6631

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The engraftment and differentiation of transplanted bone marrow-derived cells in the olfactory bulb after methimazole administration2013

    • Author(s)
      Noda Y, Nishizaki K, Yoshinobu J, Orita Y, Tsujigiwa H, Yamada M
    • Journal Title

      Acta Otolaryngol

      Volume: 133(9) Issue: 9 Pages: 951-956

    • DOI

      10.3109/00016489.2013.803153

    • NAID

      120005359096

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Role of Bone Marrow-Derived Cells During the Bone Healing Process in the GFP Mouse Bone Marrow Transplantation Model.2013

    • Author(s)
      Tsujigiwa H
    • Journal Title

      Calcif Tissue Int.

      Volume: 92 Issue: 3 Pages: 296-306

    • DOI

      10.1007/s00223-012-9685-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] GFP骨髄移植マウスを用いた、異所性骨形成過程における骨髄由来細胞の役割の検討2015

    • Author(s)
      松田寛之、辻極秀次、高畠清文、伊藤 聡、藤井昌江、野敬介、長塚 仁
    • Organizer
      硬組織再生生物学会(第24回)
    • Place of Presentation
      大阪府
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 移植骨髄由来細胞の唾液腺組織への移行、分化に関する研究2014

    • Author(s)
      伊藤 聡、辻極秀次、武部祐一郎、高畠清文、河合穂高、玉村 亮、長塚 仁
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      千葉県
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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