| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Expression of SALL4（sal-like4） mRNA in primary oral squamous cell carcinoma (OSCC) specimens was found to be significantly correlated Mode of Invasion and indicated of a relation of malignant potential. Fluorescence-activated cell sorter analysis demonstrated the existence of SP in OSCC cells and the expression of SALL4, which is associated with embryonic development and induced pluripotent stem (iPS) cells, was significantly upregulated in SP cells as compared with non-SP cells. We demonstrated that chemoresistance to 5-fluorouracil agents was weakened by inhibition of SALL4 in the 5-FU-resistant OSCC cell lines and expression of Bmi-1 was activated by SALL4. We presented SALL4 may also represent a therapeutic target of chemoresistance at 22th International Conference on Oral and Maxillofacial Surgery.
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