A new treatment strategy focused on the novel oncogene SALL4 in oral squamous cell carcinoma
| Project/Area Number |
25463093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
OTA KAZUTOSHI 熊本大学, 医学部附属病院, その他 (20336209)
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| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA Masanori 熊本大学, 医学部附属病院, 非常勤診療医師 (90117127)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 口腔扁平上皮癌 / SALL4 / 抗癌剤耐性 / Bmi-1 |
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| Outline of Final Research Achievements |
Expression of SALL4（sal-like4） mRNA in primary oral squamous cell carcinoma (OSCC) specimens was found to be significantly correlated Mode of Invasion and indicated of a relation of malignant potential. Fluorescence-activated cell sorter analysis demonstrated the existence of SP in OSCC cells and the expression of SALL4, which is associated with embryonic development and induced pluripotent stem (iPS) cells, was significantly upregulated in SP cells as compared with non-SP cells. We demonstrated that chemoresistance to 5-fluorouracil agents was weakened by inhibition of SALL4 in the 5-FU-resistant OSCC cell lines and expression of Bmi-1 was activated by SALL4. We presented SALL4 may also represent a therapeutic target of chemoresistance at 22th International Conference on Oral and Maxillofacial Surgery.
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Report
(4 results)
Research Products
(1 results)
