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Studies in experimental animals of oral cancer metastasis suppression using a nutritional immunity (EPA)

Research Project

Project/Area Number 25463114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKumamoto University

Principal Investigator

Ogi Hidenao  熊本大学, 大学院生命科学研究部(医), 助教 (10315426)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔がん / 転移 / EPA / TNF-α / TNFR1 / 扁平上皮癌 / 栄養免疫 / 口腔扁平上皮がん / 舌癌 / NF-κB
Outline of Final Research Achievements

Cancer cells (GSAS/N5) increased invasive activity 7-fold in a TNF-α receptor TNFR1-dependent manner and enhanced TNF- α and TNFR1 mRNA expression. In the highly metastatic cells, NF-B activation was up-regulated via elevated phosphorylation of Akt and Ikk/ in the signaling pathway and secretion of TNF-α ,active MMP-2 and MMP-9 increased.; TNF- activates NF-κB and activated NF-κB induces further TNF- secretion, leading to increase of active MMP release and promotion of invasion and metastasis of the cells. GSAS/N5 cells that were injected into the nude mouse tongue and harvested from metastasized lungs multiplied angiopoietin-like 4 (angptl4) expression with enhanced migration activity, which indicated a possible involvement of angptl4 in lung metastasis of the cells. These results suggest that TNF-α and angptl4 promote metastasis of the oral cancer cells, thus these molecules may be therapeutic targets for patients with tongue cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS2015

    • Author(s)
      Yoshitake, Y., Fukuma, D., Yuno, A., Hirayama, M., Nakayama, H., Tanaka. T., Nagata, M., Takamune, Y., Kawahara, K., Nakagawa, Y., Yoshida, R., Hirosue, A., Ogi, H., Hiraki, A. , Jono, H., Hamada, A., Yoshida, K., Nishimura, Y., Nakamura, Y., Shinohara, M.
    • Journal Title

      Clinical Cancer Research

      Volume: 21 Issue: 2 Pages: 312-321

    • DOI

      10.1158/1078-0432.ccr-14-0202

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Highly metastatic oral squamous carcinoma with autocrine of TNF-α acquire high invasion ability2015

    • Author(s)
      田中 拓也
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高転移性口腔扁平上皮癌はTNF-αの高発現によって高浸潤能を獲得している2015

    • Author(s)
      田中拓也 中山秀樹 永田将士 吉田遼司 川原健太 中川純泰 松岡祐一郎 尾木秀直 平木昭吉武義泰 篠原正徳
    • Organizer
      第33回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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