Studies in experimental animals of oral cancer metastasis suppression using a nutritional immunity (EPA)
| Project/Area Number |
25463114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
Ogi Hidenao 熊本大学, 大学院生命科学研究部(医), 助教 (10315426)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔がん / 転移 / EPA / TNF-α / TNFR1 / 扁平上皮癌 / 栄養免疫 / 口腔扁平上皮がん / 舌癌 / NF-κB |
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| Outline of Final Research Achievements |
Cancer cells (GSAS/N5) increased invasive activity 7-fold in a TNF-α receptor TNFR1-dependent manner and enhanced TNF- α and TNFR1 mRNA expression. In the highly metastatic cells, NF-B activation was up-regulated via elevated phosphorylation of Akt and Ikk/ in the signaling pathway and secretion of TNF-α ,active MMP-2 and MMP-9 increased.; TNF- activates NF-κB and activated NF-κB induces further TNF- secretion, leading to increase of active MMP release and promotion of invasion and metastasis of the cells. GSAS/N5 cells that were injected into the nude mouse tongue and harvested from metastasized lungs multiplied angiopoietin-like 4 (angptl4) expression with enhanced migration activity, which indicated a possible involvement of angptl4 in lung metastasis of the cells. These results suggest that TNF-α and angptl4 promote metastasis of the oral cancer cells, thus these molecules may be therapeutic targets for patients with tongue cancer.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS2015
Author(s)
Yoshitake, Y., Fukuma, D., Yuno, A., Hirayama, M., Nakayama, H., Tanaka. T., Nagata, M., Takamune, Y., Kawahara, K., Nakagawa, Y., Yoshida, R., Hirosue, A., Ogi, H., Hiraki, A. , Jono, H., Hamada, A., Yoshida, K., Nishimura, Y., Nakamura, Y., Shinohara, M.
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Journal Title
Clinical Cancer Research
Volume: 21
Issue: 2
Pages: 312-321
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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