Identification of the immunosuppressive factors which may predicit the prognosis in oral cancer patients, e.g. IL-8

• Project/Area Number: 25463119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kitasato University (2014-2015); Keio University (2013)
• Principal Investigator: Okamoto Masto 北里大学, 薬学部, 特任教授 (10243718)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: IL-8 / 口腔癌 / 腫瘍免疫 / 癌微小環境 / マクロファージ / 癌患者の免疫状態 / IL-6 / 免疫療法 / M2マクロファージ / 顆粒球 / 免疫抑制 / バイオマーカー / CD163 / 微小環境

Outline of Final Research Achievements

The immunological status is closely associated with the prognosis of cancer patients. We investigated whether serum IL-8 reflects the tumor microenvironment and has prognostic value in 50 patients with resectable oral squamous cell carcinoma (OSCC). We found that the relapse-free survival (RFS) was significantly longer in the Stage I/II OSCC patients with low serum IL-8 levels compared to those with high levels. The tumor expression of IL-8, the infiltration of CD163-positive cells, and of CD66b-positive cells in the tumor tissues were correlated with the serum IL-8 level, and they were associated with poor clinical outcome in all patients. These findings indicate that IL-8 may be involved in poor clinical outcomes via the generation of CD163-positive M2 macrophages and CD66b-overexpressing, arginase-producing granulocytes, and that these factors may have prognostic value as well as may be new targets for treatment in patients with resectable OSCC.

Research Products

• [Journal Article] Dendritic cell-based vaccine for pancreatic cancer in Japan. (2016)
  • Author(s): Okamoto M, Kobayashi M, Yonemitsu Y, Koido S, Homma S
  • Journal Title: World J Gastrointest Pharmacol Ther Volume: 7 Issue: 1 Pages: 133-8
  • DOI: 10.4292/wjgpt.v7.i1.133
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Wilms’ tumor 1 (WT1)-targeted cancer vaccines to extend survival for patients with pancreatic cancer (2016)
  • Author(s): Koido S, Okamoto M, Shimodaira S, Sugiyama H.
  • Journal Title: Immunotherapy Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An update on dendritic cell-based cancer immunotherapy (2016)
  • Author(s): Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Yanagisawa R, Okamoto M, Koido S
  • Journal Title: Immunome Res Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Quality verification of dendritic cell-based cancer vaccine. (2016)
  • Author(s): Shimodaira S, Koya T, Higuchi Y, Okamoto M, Koido S
  • Journal Title: Pharm Anal Acta Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy of dendritic cell-based cancer immunotherapy (2016)
  • Author(s): Shimodaira S, Higuchi Y, Yanagisawa R, Okamoto M, Koido S
  • Journal Title: Biochem Anal Biochem Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dendritic cell-based vaccine for colorectal cancer. (2016)
  • Author(s): Kajihara M, Takakura K, Kanai T, Ito Z, Saito K, Takami S, Shimodaira S, Okamoto M, Ohkusa T, Koido S
  • Journal Title: World J Gastroenterol Volume: 22 Issue: 17 Pages: 4275-4286
  • DOI: 10.3748/wjg.v22.i17.4275
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Advances in inducing adaptive immunity using cell-based cancer vaccine: Clinical applications in pancreatic cancer. (2016)
  • Author(s): Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido S.
  • Journal Title: World J Gastroenterol Volume: 22 Issue: 18 Pages: 4446-4458
  • DOI: 10.3748/wjg.v22.i18.4446
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive assessment of the prognosis of pancreatic cancer: Peripheral blood neutrophil-lymphocyte ratio and immunohistochemical analyses of the tumour site (2016)
  • Author(s): Takakura K, Ito Z, Suka M, Kanai T, Matsumoto Y, Odahara S, Matsudaira H, Haruki K, Fujiwara Y, Saito R, Gocho T, Nakashiro K, Hamakawa H, Okamoto M, Kajihara M, Misawa T, Ohkusa T, Koido S
  • Journal Title: Scand J Gastroenterol Volume: 51 Issue: 5 Pages: 610
  • DOI: 10.3109/00365521.2015.1121515
  • URL: https://pure.teikyo.jp/en/publications/0ca8da8a-105b-4ade-984f-d81b5c1adcf4
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 癌ワクチンとチェックポイント阻害剤の併用に関する検討 (2016)
  • Author(s): 岡本正人
  • Journal Title: Pharm Stage Volume: 15 Pages: 54-59
• [Journal Article] Up-regulation of HER2 by gemcitabine enhances the anti tumor effect of combined gemcitabine and trastumabemtasine treatment on pancreatic ductal adenocarcinoma cells. (2015)
  • Author(s): Kan S, Koido S, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Nagasaki E, Homma S.
  • Journal Title: BMC Cancer. Volume: 15 Issue: 1 Pages: 726-726
  • DOI: 10.1186/s12885-015-1772-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy. (2015)
  • Author(s): Tsukinaga S, Kajihara M, Takakura K, Ito Z, Kanai T, Saito K, Takami S, Kobayashi H, Matsumoto Y, Odahara S, Uchiyama K, Arakawa H, Okamoto M, Sugiyama H, Sumiyama K, Ohkusa T, Koido S
  • Journal Title: World J Gastroenterol Volume: 21 Issue: 39 Pages: 11168-78
  • DOI: 10.3748/wjg.v21.i39.11168
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Gemcitabine treatment enhances HER2 expression in low HER2-expressing breast cancer cells and enhances the anti tumor effects of traszumab emtasine. (2015)
  • Author(s): Kan S, Koido S, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Nagasaki E, Homma S.
  • Journal Title: Oncol Rep. Volume: 34 Issue: 1 Pages: 504-10
  • DOI: 10.3892/or.2015.3974
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dendritic cell-based immunotherapy targeting Wilms' Tumor 1 (WT1) in patients with relapsed malignant glioma. (2015)
  • Author(s): Sakai K, Shimodaira S, Maejima S, Udagawa N, Sano K, Higuchi Y, Koya T, Ochiai T, Koide M, Uehara S, Nakamura M, Sugiyama H, Yonemitsu Y, Okamoto M, Hongo K.
  • Journal Title: J Neurosurg Volume: 123 Issue: 4 Pages: 989-997
  • DOI: 10.3171/2015.1.jns141554
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer. (2015)
  • Author(s): Mayanagi S, Kitago M, Sakurai T, Matsuda T, Fujita T, Higuchi H, Taguchi J, Takeuchi H, Itano O, Aiura K, Hamamoto Y, Takaishi H, Okamoto M, Sunamura M, Kawakami Y, Kitagawa Y.
  • Journal Title: Cancer Science Volume: 106 Issue: 4 Pages: 397-406
  • DOI: 10.1111/cas.12621
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Safety and tolerability of allogeneic dendritic cell vaccination with induction of WT1-specific T cells in a pediatric donor and pediatric patient with relapsed leukemia: A case report and review of the literature. (2015)
  • Author(s): Saito S, Yanagisawa R, Yoshikawa K, Higuchi Y, Koya T, Yoshizawa K, Tanaka M, Sakashita K, Kobayashi T, Kurata T, Hirabayashi K, Nakazawa Y, Shiohara M, Yonemitsu Y, Okamoto M, Sugiyama S, Koike K, Shimodaira S.
  • Journal Title: Cytotherapy Volume: 17 Issue: 3 Pages: 330-335
  • DOI: 10.1016/j.jcyt.2014.10.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] アフェレーシス検体から血中循環癌細胞の分離、培養の試み (2015)
  • Author(s): 征矢良子、田口淳一、永川裕一、高橋 修、山洞典正、細川勇一、粕谷和彦、梅田尚季、岡本正人、辻谷俊一、土田明彦
  • Journal Title: 癌と化学療法 Volume: 42 Pages: 1069-1072
  • Peer Reviewed
• [Journal Article] 日本発樹状細胞がんワクチンVaccell®の臨床応用 (2015)
  • Author(s): 岡本正人
  • Journal Title: W`Wave Volume: 21 Pages: 27-30
  • Peer Reviewed
• [Journal Article] Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell carcinoma (2014)
  • Author(s): Fujita Y, Okamoto M, Goda H, Tano T, Nakashiro K, Sugita A, Fujita T, Koido S, Homma S, Kawakami Y, Hamakawa H.
  • Journal Title: PLoS ONE Volume: 9 Issue: 12 Pages: e110378-e110378
  • DOI: 10.1371/journal.pone.0110378
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic effect of intratumoral injections of dendritic cells for locally recurrent gastric cancer: a case report. (2014)
  • Author(s): Kobayashi M, Sakabe T, Chiba A, Nakajima A, Okamoto M, Shimodaira S, Yonemitsu Y, Shibamoto Y, Suzuki N, Nagaya M.
  • Journal Title: World J Surg Oncol Volume: 12 Issue: 1 Pages: 390-390
  • DOI: 10.1186/1477-7819-12-390
  • Peer Reviewed
• [Journal Article] The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma (2014)
  • Author(s): Tada Y, Kokabu S, Sugiyama G, Nakatomi C, Aoki K, Fukushima H, Osawa K, Sugamori Y, Ohya K, Okamoto M, Fujikawa T, Itai A, Matsuo K, Watanabe S, Jimi E
  • Journal Title: Oncotarget Volume: 5 Pages: 12317-12330
  • Peer Reviewed
• [Journal Article] Prognostic markers for patient outcome following vaccination with multiple MHC class I/II-restricted WT1 peptide-pulsed dendritic cells plus chemotherapy for pancreatic cancer (2014)
  • Author(s): Takakura K, Koido S, Kan S, Yoshida K, Mori M, Hirano Y, Ito Z, Kobayashi H, Takami S, Matsumoto Y, Kajihara M, Misawa T, Okamoto M, Homma S, Ohkusa T, Tajiri H
  • Journal Title: Anticancer Res Volume: 35 Pages: 555-562
  • Peer Reviewed
• [Journal Article] Predictive biomarkers for the outcome of vaccination of five therapeutic epitope peptides for colorectal cancer (2014)
  • Author(s): Hazama S, Takenouchi H, Tsunedomi R, Iida M, Suzuki N, Iizuka N, Inoue Y, Sakamoto K, Nakao M, Shindo Y, Kanekiyo S, Tokumitsu Y, Yoshimura K, Maeda N, Maeda K, Maeda Y, Matsui H, Yoshino S, Nakamura Y, Fujita Y, Hamamoto Y, Okamoto M, Fujita T, Kawakami Y, Oka M
  • Journal Title: Anticancer Res Volume: 34 Pages: 4201-4205
  • Peer Reviewed
• [Journal Article] Immunogenic assessment of cryotherapy in breast cancer patients (2014)
  • Author(s): Koido S, Kinoshita S, Mogami T, Kan S, Takakura K, Okamoto M, Homma S, Ohkusa T, Tajiri H, Harada J
  • Journal Title: Anticancer Res Volume: 34 Pages: 4869-4876
  • Peer Reviewed
• [Journal Article] Immunogenic modulation of cholangiocarcinoma cells by chemoimmunotherapy (2014)
  • Author(s): Koido S, Kan S, Yoshida K, Yoshizaki S, Takakura K, Tsukinaga S, Odahara S, Kajihara M, Okamoto M, Ito M, Yusa S, Ohkusa T, Gong J, Homma S, Tajiri H.
  • Journal Title: Anticancer Res Volume: 34 Pages: 6353-6361
  • Peer Reviewed
• [Journal Article] Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II- restricted epitopes for pancreatic cancer (2014)
  • Author(s): Koido S, Homma S et al.
  • Journal Title: Clin Cancer Res Volume: 20 Issue: 16 Pages: 4228
  • DOI: 10.1158/1078-0432.ccr-14-0314
  • URL: https://localhost/en/publications/3ee9a72d-5974-4d66-88c6-d7ad5f3e50df
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Production of corticotropin-released factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine. (2014)
  • Author(s): Koido S, Ohkusa T, Kan S, Takakura K, Saito K, Komita H, Ito Z, Kobayashi H, Takami S, Uchiyama K, Arakawa H, Ito M, Okamoto M, Kajihara M, Homma S, Tajiri H.
  • Journal Title: World J Gastroenterol. Volume: 20 Issue: 39 Pages: 14420-9
  • DOI: 10.3748/wjg.v20.i39.14420
  • Peer Reviewed
• [Journal Article] The feasibility and clinical effects of dendritic cell-based immunotherapy targeting synthesized peptides for recurrent ovarian cancer. (2014)
  • Author(s): Kobayashi M, Chiba A, Izawa H, Yanagida E, Okamoto M, Shimodaira S, Yonemitsu Y, Shibamoto Y, Suzuki N, Nagaya M; The DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT).
  • Journal Title: J Ovarian Res Volume: 7 Issue: 1 Pages: 48-48
  • DOI: 10.1186/1757-2215-7-48
  • Peer Reviewed / Open Access
• [Journal Article] Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells. (2014)
  • Author(s): Koido S, Homma S et al.
  • Journal Title: Int J Oncol Volume: 45 Issue: 1 Pages: 470-478
  • DOI: 10.3892/ijo.2014.2433
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Vaccination with vascular progenitor cells derived from induced pluripotent stem cells elicits antitumor immunity targeting vascular and tumor cells. (2014)
  • Author(s): 1.Koido S, Ito M, Sagawa Y, Okamoto M, Hayashi K, Nagasaki E, Kan S, Komita H, Kamata Y, Homma S.
  • Journal Title: Cancer Immunology Immunotherapy Volume: 63 Issue: 5 Pages: 459-468
  • DOI: 10.1007/s00262-014-1531-1
  • Peer Reviewed
• [Journal Article] Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy: a multicenter analysis. (2014)
  • Author(s): Kobayashi M, Shimodaira S, Nagai K, Ogasawara M, Takahashi H, Abe H, Tanii M, Okamoto M, Tsujitani S, Yusa S, Ishidao T, Kishimoto J, Shibamoto Y, Nagaya M, Yonemitsu Y; DC Vaccine Study Group at the Japan Society of Innovative Cell Therapy (J-SICT).
  • Journal Title: Cancer Immunol Immunother Volume: 63 Issue: 8 Pages: 797-806
  • DOI: 10.1007/s00262-014-1554-7
  • Peer Reviewed
• [Journal Article] Vaccination with vascular progenitor cells derived from induced pluripotent stem cells elicits antitumor immunity targeting vascular and tumor cells. (2014)
  • Author(s): Koido S, Ito M, Sagawa Y, Okamoto M, Hayashi K, Nagasaki E, Kan S, Komita H, Kamata Y, Homma S.
  • Journal Title: Cancer Immunol Immunother Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy: a multicenter analysis. (2014)
  • Author(s): Kobayashi M, Shimodaira S, Nagai K, Ogasawara M, Takahashi H, Abe H, Tanii M, Okamoto M, Tsujitani S, Yusa S, Ishidao T, Kishimoto J, Shibamoto Y, Nagaya M, Yonemitsu Y.
  • Journal Title: Cancer Immunol Immunother, Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Dendritic cell-based immunotherapy targeting synthesized peptides for advanced biliary tract cancer (2013)
  • Author(s): Kobayashi M, Sakabe T, Abe H, Tanii M, Takahashi H, Chiba A, Yanagida E,Shibamoto Y, Ogasawara M, Tsujitani S, Koido S, Nagai K, Shimodaira S, Okamoto M,Yonemitsu Y, Suzuki N, Nagaya M; DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT).
  • Journal Title: J Gastrointest Surg Volume: 17(9) Issue: 9 Pages: 1609-17
  • DOI: 10.1007/s11605-013-2286-2
  • Peer Reviewed
• [Journal Article] Immuno-Chemoradiotherapy for Patients with Oral Squamous Cell Carcinoma: Augmentation of OK-432-Induced Helper T-Cell 1 Response by 5-FU and X-Ray Irradiation. (2013)
  • Author(s): Tano T, Okamoto M, Kan S, Bando T, Goda H, Nakashiro K, Shimodaira S, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Sato M, Yamashita N, Hamakawa H, Kawakami Y.
  • Journal Title: Neoplasia Volume: 15 Pages: 805-814
  • Peer Reviewed
• [Journal Article] Augmentation of Antitumor Immunity by Fusions of Ethanol-Treated Tumor Cells and Dendritic Cells Stimulated via Dual TLRs through TGF-β1 Blockade and IL-12p70 Production (2013)
  • Author(s): Koido S, Homma S, Okamoto M et al.
  • Journal Title: PLoS ONE Volume: 8 Issue: 5 Pages: e63498-e63498
  • DOI: 10.1371/journal.pone.0063498
  • URL: https://pure.teikyo.jp/en/publications/ded0dc73-68ee-4120-b003-af8bf5053efc
  • Peer Reviewed
• [Journal Article] Immune-maximizing (IMAX) therapy for cancer: Combination of dendritic-cell vaccine and intensity-modulated radiation. (2013)
  • Author(s): Shibamoto Y, Okamoto M, Kobayashi M, Ayakawa S, Iwata H, Sugie C, Mitsuishi Y, Takahashi H.
  • Journal Title: Mol Clin Oncol, Volume: 1 Pages: 649-654
  • Peer Reviewed
• [Journal Article] Combined TLR2/4-Activated Dendritic/Tumor Cell Fusions Induce Augmented Cytotoxic T Lymphocytes (2013)
  • Author(s): Shigeo Koido
  • Journal Title: PLOS ONE Volume: 8 Issue: 3 Pages: e59280-e59280
  • DOI: 10.1371/journal.pone.0059280
  • URL: https://pure.teikyo.jp/en/publications/a0536fb4-5883-4b7a-91d7-d3aca420b161
  • Peer Reviewed
• [Journal Article] Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma. (2013)
  • Author(s): Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Kawakami Y, Hamakawa H.
  • Journal Title: Neoplasia Volume: 15 Pages: 305-314
  • Peer Reviewed
• [Journal Article] Eur J Cancer (2013)
  • Author(s): Hidenori Takahashi
  • Journal Title: 10.1016/j.ejca.2012.11.005 Volume: 49 Issue: 4 Pages: 852-859
  • DOI: 10.1016/j.ejca.2012.11.005
  • Peer Reviewed
• [Presentation] 化学療法あるいはチェックポイント阻害剤＋がんワクチン併用プロトコールの確立と臨床評価 (2016)
  • Author(s): 岡本正人
  • Organizer: 技術情報協会セミナー「がん免疫療法における併用療法の開発」
  • Place of Presentation: 日幸五反田ビル8階会議室、東京
  • Year and Date: 2016-03-24
  • Invited
• [Presentation] 臨床試験におけるバイオマーカー探索 (2016)
  • Author(s): 岡本正人
  • Organizer: 鳥取大学医学部附属病院がんセンターがん免疫セミナー「がん免疫細胞治療の臨床試験をめざして」
  • Place of Presentation: 鳥取大学医学部附属病院がんセンター、鳥取
  • Year and Date: 2016-03-05
  • Invited
• [Presentation] 新規がん抗原探索システムの構築～癌ワクチン、TCR/CAR遺伝子療法ならびに抗体治療への応用～ (2015)
  • Author(s): 岡本正人
  • Organizer: 第35回白金シンポジウム
  • Place of Presentation: 北里大学薬学部第１号棟1階、東京
  • Year and Date: 2015-12-22
• [Presentation] 癌治療における免疫抑制解除技術の開発～抗体医薬品、既存の医薬品、漢方薬等の癌治療への応用～ (2015)
  • Author(s): 岡本正人
  • Organizer: 第35回白金シンポジウム
  • Place of Presentation: 北里大学薬学部第１号棟1階、東京
  • Year and Date: 2015-12-22
• [Presentation] Anti-interleukin-6 receptor antibody suppressed oral squamous cell carcinoma by inhibiting tumor-stroma interaction (2015)
  • Author(s): Goda H, Okamoto M, Nakashiro K, Tozuka N, Hamakawa H
  • Organizer: ESMO Asia 2015 Congress
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre, Singapore
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] 癌に対する免疫・細胞治療～最近のトピックス～ (2015)
  • Author(s): 岡本正人
  • Organizer: 第4回日本免疫・細胞治療学会総会
  • Place of Presentation: ベルサール九段、東京
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] 癌炎症病態の解明とそのバイオマーカーとしての意義～末梢血と癌微小環境 (2015)
  • Author(s): 岡本正人、藤田知信、野路しのぶ、南雲春菜、桜井敏晴、合田啓之、中城公一、浜川裕之、河上裕
  • Organizer: 第28回日本バイオセラピィ学会学術集会総会シンポジウム１【癌と炎症病態の解明と治療】
  • Place of Presentation: 川越東武ホテル、埼玉
  • Year and Date: 2015-12-03
• [Presentation] 進行期非小細胞肺癌患者に対する樹状細胞ワクチンによる臨床的有用性および予後因子の検討：多施設共同研究 (2015)
  • Author(s): 高橋秀徳、下平滋隆、小笠原正浩、小林正学、阿部浩文、長井一浩、岡本正人、辻谷俊一、森田祐二、米満吉和
  • Organizer: 第28回日本バイオセラピィ学会学術集会総会ワークショップ３「がんワクチン療法を考える」
  • Place of Presentation: 川越東武ホテル、埼玉
  • Year and Date: 2015-12-03
• [Presentation] 治癒切除後膵臓癌に対するWT1およびMUC1ペプチドパルス樹状細胞免疫療法の術後アジュバント療法としての有用性 (2015)
  • Author(s): 長井一浩、北里周、原田浩、足立智彦、黒木保、岡本正人、宮崎泰司、江口晋
  • Organizer: 第28回日本バイオセラピィ学会学術集会総会要望演題１「がんワクチン療法の今を知る」
  • Place of Presentation: 川越東武ホテル、埼玉
  • Year and Date: 2015-12-03
• [Presentation] 局所再発胃癌に対する樹状細胞腫瘍内局注療法の1例報告 (2015)
  • Author(s): 小林正学、、岡本正人、下平滋隆、米満吉和、長屋昌樹
  • Organizer: 第28回日本バイオセラピィ学会学術集会総会一般演題３「がんワクチン療法のこれからを考える」
  • Place of Presentation: 川越東武ホテル、埼玉
  • Year and Date: 2015-12-03
• [Presentation] Dual role of soluble IL2Rα as a biomarker for cancer immunotherapy (2015)
  • Author(s): Nagumo H, Fujita T, Sakurai T, Noji S, Okamoto M, Matsueda S, Sasada T, Itoh K, Kawakami Y
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2015-11-18
• [Presentation] チェックポイント阻害剤と他の免疫療法との併用療法の開発～チェックポイント阻害剤＋がんワクチンの検討～ (2015)
  • Author(s): 岡本正人
  • Organizer: 技術情報協会セミナー「免疫チェックポイント阻害剤の開発と試験デザイン」
  • Place of Presentation: 日幸五反田ビル8階会議室、東京
  • Year and Date: 2015-11-12
  • Invited
• [Presentation] Development of dendritic cell-based cancer vaccine in Japan (2015)
  • Author(s): Masato Okamoto
  • Organizer: International Conference on Vaccines R&D-2015,[Cancer Vaccines & Clinical Trials]
  • Place of Presentation: The Double Tree by Hilton Baltimore-BWI Airport, Baltimore, MD, USA
  • Year and Date: 2015-11-02
  • Int'l Joint Research / Invited
• [Presentation] 口腔扁平上皮癌における腫瘍関連線維芽細胞の臨床的意義 (2015)
  • Author(s): 合田啓之、岡本正人、徳善紀彦、中城公一、浜川裕之
  • Organizer: 第53回日本癌治療学会学術集会【ワークショップ】WS-99頭頸・口腔３
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2015-10-29
• [Presentation] IV期メラノーマに対するカルボプラチン・パクリタキセル併用樹状細胞ワクチン療法 (2015)
  • Author(s): 福田桂太郎、船越建、桜井敏晴、中村善雄、森真理子、谷川瑛子、藤田知信、田口淳一、岡本正人、天谷雅行、河上裕
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場、愛知
  • Year and Date: 2015-10-08
• [Presentation] がん免疫療法の現状～当院で実施される樹状細胞がんワクチン療法を中心に～ (2015)
  • Author(s): 岡本正人
  • Organizer: 北里研究所病院腫瘍センター主催 第5回市民公開講座、知っておこう！～膵臓がんの今を知る～
  • Place of Presentation: 北里大学薬学部第2号館3階大講義室、東京
  • Year and Date: 2015-10-01
  • Invited
• [Presentation] 免疫の力でがんと闘う～ここまで進んだ免疫療法～ (2015)
  • Author(s): 岡本正人
  • Organizer: ハウステンボス健康と美の王国「大健康祭り」【特別講演会】
  • Place of Presentation: ハウステンボス、長崎
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] Phase I/II pilot study of peptide-pulsed dendritic cell vaccination in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma (2015)
  • Author(s): Fukuda K, Funakoshi T, Sakurai T, Nakamura Y, Mori M, Tanikawa A, Fujita T, Taguchi J, Okamoto M, Amagai M, Kawakami Y
  • Organizer: ICCIM2015 (International Conference of Cancer Immunotherapy and Macrophages 2015)
  • Place of Presentation: Ito International Research Center, The University of Tokyo, Toyko
  • Year and Date: 2015-07-09
  • Int'l Joint Research
• [Presentation] 日本発の樹状細胞ワクチンVaccell®の治療効果～膵癌を中心に～ (2015)
  • Author(s): 岡本正人、小林正学、米満吉和、小井戸薫雄、本間 定
  • Organizer: 第24回日本癌病態治療研究会【シンポジウム１】基礎から臨床へのトランスレーショナルリサーチ「橋渡し研究」
  • Place of Presentation: 日光千姫物語、栃木
  • Year and Date: 2015-06-25
• [Presentation] J-SICTの歩みと日本免疫・細胞治療学会のミッション (2015)
  • Author(s): 岡本正人
  • Organizer: 免疫・細胞治療セミナー（日本免疫・細胞治療学会主催）
  • Place of Presentation: トラストシティカンファランス京橋、東京
  • Year and Date: 2015-06-13
  • Invited
• [Presentation] Prognostic significance of interleukin-8 and infiltration of immune cells positive for CD163 and CD66b in tumor tissues in patients with oral squamous cell carcinoma (2015)
  • Author(s): Okamoto M, Fujita Y, Goda H, Nakashiro K, Hamakawa H
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, PA, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] バイオマーカー探索 (2015)
  • Author(s): 岡本正人
  • Organizer: 鳥取大学医学部付属病院がんセンター がんセミナー「がん免疫細胞治療の臨床試験をめざして」
  • Place of Presentation: 鳥取大学医学部附属病院がんセンターキャンサーボード、鳥取
  • Year and Date: 2015-03-07
  • Invited
• [Presentation] 最先端のがん治療～樹状細胞を用いたがんワクチン～ (2015)
  • Author(s): 岡本正人
  • Organizer: 第1回熊本がん治療講演会【市民公開講座】これからのがん治療
  • Place of Presentation: アークホテル熊本城前、熊本
  • Year and Date: 2015-02-21
  • Invited
• [Presentation] 私の癌免疫研究～樹状細胞ワクチンの開発と三本の矢～ (2014)
  • Author(s): 岡本正人
  • Organizer: 第3回日本イノベイティブ・セルセラピィ研究会総会
  • Place of Presentation: アーク森ビル、東京
  • Year and Date: 2014-12-13
  • Invited
• [Presentation] Gemcitabine enhanced HER2 expression and Trastuzumab Emtansine augmented anti-tumor effect against Gemcitabine-treated breast cancer cell lines with low HER2 expression (2014)
  • Author(s): Kan S, Koido S, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Nagasaki E, Homma S
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] 最先端のがん治療～樹状細胞を用いたがんワクチン～ (2014)
  • Author(s): 岡本正人
  • Organizer: 名古屋がんワクチン治療講演会【市民公開講座】 癌治療情報最前線～進化を続けるがんワクチン～
  • Place of Presentation: 安保ホール、名古屋
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] 樹状細胞ワクチン療法の治療効果と化学免疫療法の開発：化学療法剤によるチェックポイント分子の修飾 (2014)
  • Author(s): 岡本正人、藤田陽平、合田啓之、中城公一、浜川裕之
  • Organizer: 第27回日本バイオセラピィ学会学術集会総会, ワークショップ７「癌免疫療法効果増強のための工夫
  • Place of Presentation: ナレッジキャピタル コングレコンベンションセンター, 大阪
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] ゲムシタビンのHER2発現誘導効果を利用したHER2低発現乳癌細胞に対するトラスツズマブエムタンシンの抗腫瘍増強作用 (2014)
  • Author(s): かんしん、小井戸薫雄、岡本正人、林 和美、伊藤正紀、鎌田裕子、込田英夫、永崎栄次郎、本間 定
  • Organizer: 第27回日本バイオセラピィ学会学術集会総会、ワークショップ１「抗体療法」
  • Place of Presentation: ナレッジキャピタル コングレコンベンションセンター, 大阪
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] 治癒切除後の膵臓癌に対するWT1ペプチドパルス樹状細胞ワクチン療法に関する第II相試験 (2014)
  • Author(s): 下平滋隆、長井一浩、小笠原正浩、杉山治夫、米満吉和、岡本正人、辻谷俊一
  • Organizer: 第27回日本バイオセラピィ学会学術集会総会、ワークショップ２「ワクチン療法」
  • Place of Presentation: ナレッジキャピタル コングレコンベンションセンター, 大阪
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] 切除不能な進行膵臓癌に対する樹状細胞ワクチン療法の有用性と予後因子の検討 (2014)
  • Author(s): 小林正学、下平滋隆、長井一浩、小笠原正浩、高橋秀徳、阿部浩文、谷井 貢、岡本正人、辻谷俊一、長屋昌樹、米満吉和
  • Organizer: 第27回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: ナレッジキャピタル コングレコンベンションセンター、大阪
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] 樹状細胞療法残渣検体からのCTC分離・培養の試み (2014)
  • Author(s): 征矢良子、高橋 修、細川勇一、永川裕一、勝又健次、山洞典正、岡本正人、辻谷俊一、田口淳一、土田明彦
  • Organizer: 第27回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: ナレッジキャピタル コングレコンベンションセンター、大阪
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] がん免疫療法と歯科医師・岡本 (2014)
  • Author(s): 岡本正人
  • Organizer: 平成26年度徳島大学歯学部 進学就職ガイダンス・特別講演会
  • Place of Presentation: 徳島大学歯学部４階大講義室、徳島
  • Year and Date: 2014-11-20
  • Invited
• [Presentation] HER2 up-regulation by gemcitabine augments antitumor effect of trastuzumab emtansine against low HER2 breast cancer cell (2014)
  • Author(s): Kan S, Koido K, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Nagasaki E, Homma S
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Treatment with dendritic cells pulsed with multiple WT1-specific MHC class I/II-epitopes for pancreatic cancer (2014)
  • Author(s): Koido K, Homma S, Okamoto M, Ishidao T, Shimodaira S, Kan S, Ito M, Sugiyama H, Ohkusa T, Tajiri H.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] A first line treatment of pancreatic cancer by WT1 peptide-pulsed dendritic cell vaccine combined with gemcitabine (2014)
  • Author(s): Mayanagi S, Sakurai T, Kitago M, Matsuda T, Fujita T, Higuchi H, Taguchi J, Takeuchi H, Itano O, Okamoto M, Sunamura M, Kawakami Y, Kitagawa Y
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 切除不能な進行・再発胆道癌65例に対する人工抗原を用いた樹状細胞ワクチン療法 (2014)
  • Author(s): 小林 正学、坂部 知代、阿部 浩文、高橋 秀徳、千葉 麻子、下平 滋隆、岡本 正人、米満 吉和、長屋 昌樹
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Tumor infiltrations of T-cells are immune-biomarkers for prognosis of colon cancer patients (2014)
  • Author(s): Fujita T, Xu M, Popivanova B, Okamoto M, Sakurai T, Torigoe T, Sato N, Sugiura F, Okuno K, Hazama S, Oka M, Kawakami Y
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] がん免疫細胞治療の現状とこれから (2014)
  • Author(s): 岡本正人
  • Organizer: 八王子がん治療講演会【市民公開講座】がんとどう向き合い、どう付き合うか
  • Place of Presentation: 京王プラザホテル八王子、東京
  • Year and Date: 2014-09-20
  • Invited
• [Presentation] Combination treatment by chemotherapy and dendritic cells pulsed with multiple Wilms’ tumor gene 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer (2014)
  • Author(s): Koido K, Homma S, Okamoto M, Shimodaira S, Sugiyama H, Ohkusa T, Tajiri H
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] 切除不能膵臓癌に対する樹状細胞ワクチン療法：多施設共同研究 (2014)
  • Author(s): 小林 正学、下平 滋隆、長井 一浩、小笠原 正浩、高橋 秀徳、阿部 浩文、谷井 貢、岡本 正人、辻谷 俊一、遊佐 精一、石田尾 武文、岸本 淳司、長屋 昌樹、米満 吉和
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] がんペプチドワクチン後予後予測マーカーとしての治療前血中IL6・IL8 の意義 (2014)
  • Author(s): 藤田知信、野路しのぶ、南雲春奈、岡本正人、桜井敏晴、澤田雄、吉川聡明、中面哲也、野口正典、松枝智子、伊東恭悟、硲彰一、竹之内寛子、岡正朗、河上裕
  • Organizer: 第18回日本がん免疫学会総会
  • Place of Presentation: ひめぎんホール、松山
  • Year and Date: 2014-07-30 – 2014-08-01
• [Presentation] 進行再発大腸癌に対するmFOLFOX6とエピトープペプチド併用療法における血中抗ペプチド抗体の解析 (2014)
  • Author(s): 鈴木伸明、松枝智子、硲 彰一、竹之内寛子、吉田浩二、角田卓也、中村祐輔、岡本正人、藤田知信、河上 裕、伊東恭悟、岡 正朗
  • Organizer: 第18回日本がん免疫学会総会
  • Place of Presentation: ひめぎんホール、松山
  • Year and Date: 2014-07-30 – 2014-08-01
• [Presentation] Dendritic cells pulsed with WT1-specific MHC class I/II restricted epitopes for pancreatic cancer (2014)
  • Author(s): 小井戸薫雄、本間 定、岡本正人、伊東正紀、杉山治夫、大草敏史、田尻久雄
  • Organizer: 第18回日本がん免疫学会総会
  • Place of Presentation: ひめぎんホール、松山
  • Year and Date: 2014-07-30 – 2014-08-01
• [Presentation] ゲムシタビンによるHer2発現増強効果を利用した膵癌に対する新たな分子標的療法 (2014)
  • Author(s): Kan Shin、小井戸薫雄、岡本正人、林 和美、伊東正紀、蒲田 裕子、込田英夫、永崎栄次郎、本間 定
  • Organizer: 第18回日本がん免疫学会総会
  • Place of Presentation: ひめぎんホール、松山
  • Year and Date: 2014-07-30 – 2014-08-01
• [Presentation] がんワクチン療法の進歩と課題 (2014)
  • Author(s): 岡本正人
  • Organizer: 第1回関東がん免疫治療フォーラム
  • Place of Presentation: アーク森ビル、東京
  • Year and Date: 2014-07-05
  • Invited
• [Presentation] 最先端のがんワクチン治療～樹状細胞を用いたがんワクチン～ (2014)
  • Author(s): 岡本正人
  • Organizer: 名古屋がんワクチン治療講演会【市民公開講座】がんワクチンの今とこれから
  • Place of Presentation: 安保ホール、名古屋
  • Year and Date: 2014-06-21
  • Invited
• [Presentation] 【教育講演】化学療法と癌ワクチンの併用の検討：5-FUは樹状細胞における免疫抑制分子の発現を介してCTL誘導を増強する (2014)
  • Author(s): 岡本正人、藤田陽平、合田啓之、中城公一、浜川裕之
  • Organizer: 第23回日本癌病態治療研究会
  • Place of Presentation: ホテルグランヴェール岐山、岐阜
  • Year and Date: 2014-06-12 – 2014-06-13
  • Invited
• [Presentation] Interleukin-8はCD163陽性M2マクロファージを誘導する：口腔扁平上皮癌患者における予後不良因子 (2014)
  • Author(s): 岡本正人、藤田陽平、合田啓之、中城公一、浜川裕之
  • Organizer: 第23回日本癌病態治療研究会
  • Place of Presentation: ホテルグランヴェール岐山、岐阜
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] 切除不能膵臓癌255例に対する樹状細胞ワクチン療法：多施設共同研究 (2014)
  • Author(s): 小林 正学、下平 滋隆、長井 一浩、小笠原 正浩、高橋 秀徳、阿部 浩文、谷井 貢、岡本 正人、辻谷 俊一、遊佐 精一、石田尾 武文、岸本 淳司、長屋 昌樹、米満 吉和
  • Organizer: 第23回日本癌病態治療研究会
  • Place of Presentation: ホテルグランヴェール岐山、岐阜
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] がんワクチン療法の進歩と課題 (2014)
  • Author(s): 岡本正人
  • Organizer: 第1回東海がん治療フォーラム
  • Place of Presentation: 安保ホール、名古屋
  • Year and Date: 2014-06-12
  • Invited
• [Presentation] Down-regulation of PD-1 ligands by chemotherapeutic agents via inhibition of STAT3 activity enhances T cell-stimulating ability of dendritic cells (2014)
  • Author(s): Okamoto M, Tano T, Goda H, Fujita Y, Nakashiro K, Hamakawa H
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-04-05
• [Presentation] 化学療法と癌ワクチンの併用の検討：5-FUは樹状細胞における免疫抑制分子の発現を毎してCTL誘導を増強する (2014)
  • Author(s): 岡本正人、藤田陽平、合田啓之、中城公一、浜川裕之
  • Organizer: 第23回日本癌病態治療研究会（教育講演）
  • Place of Presentation: 岐阜
  • Invited
• [Presentation] Interleukin-8はCD163陽性M2マクロファージを誘導する：口腔扁平上皮癌患者における予後不良因子 (2014)
  • Author(s): 岡本正人、藤田陽平、合田啓之、中城公一、浜川裕之
  • Organizer: 第23回日本癌病態治療研究会
  • Place of Presentation: 岐阜
• [Presentation] Down-regulation of PD-1 ligands by chemotherapeutic agents via inhibition of STAT3 activity enhances T cell-stimulating ability of dendritic cells. (2014)
  • Author(s): Okamoto M, Tano T, Goda H, Fujita Y, Nakashiro K, Hamakawa H.
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego Convention Center
• [Presentation] Dendritic cells pulsed with Wilms’ tumor gene 1 (WT1)-specific and MHC class I and II-restricted epitopes with gemicitabine induce antitumor immune responses with advanced pancreatic cancer (2014)
  • Author(s): Koido S, Homma S, Okamoto M, Mori M, Yoshizaki S, Imazu H, Takakura K, Hayashi K, Kan S, Ishidao T, Yusa S, Shimodaira S, Uchiyama K, Kajihara M, Arakawa H, Ohkusa T, Tajiri H.
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego Convention Center
• [Presentation] HER2 upregulation induced by gemcitabine treatment augments antitumor effect of trastuzumab emtansine against pancreatic cancer (2014)
  • Author(s): Kan S, Koido S, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Nagasaki E, Homma S.
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego Convention Center
• [Presentation] 早期口腔癌における予後予測診断システムの開発：センチネルリンパ節生検と血清IL-6値の併用効果 (2013)
  • Author(s): 合田啓之、岡本正人、中城公一、藤田陽平、田野智之、浜川裕之
  • Organizer: 第26回バイオセラピィ学会学術集会総会
  • Place of Presentation: 盛岡アイーナ
• [Presentation] 成分採血検体からの血中循環がん細胞(CTC)検出の試み (2013)
  • Author(s): 征矢良子、高橋 修、細川勇一、永川裕一、岡本正人、辻谷俊一、田口淳一、土田明彦
  • Organizer: 第26回バイオセラピィ学会学術集会総会
  • Place of Presentation: 盛岡アイーナ
• [Presentation] The high plasma IL6 and IL8 are biomarkers for predicting poor clinical outcome of cancer patients treated with peptide cancer vaccines (2013)
  • Author(s): Fujita T, Noji S, Nagumo H, Okamoto M, Sakurai T, Noguchi M, Matsueda S, Itoh K, Hazama S, Oka M, Kawakami Y.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Strong correlation of tumor-infiltrating CD8+ and Foxp3+ T cells with favorable prognosis of patients with colon cancer (2013)
  • Author(s): Xu M, Noji S, Okamoto M, Sakurai T, Fujita T, Torigoe T, Sato N, Sugiura F, Okuno K, Hazama S, Oka M, Kawakami Y.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] センチネルリンパ節生検と血清 interleukin-6 を用いた口腔扁平上皮癌患者の予後予測 (2013)
  • Author(s): 合田啓之、岡本正人、中城公一、田野智之、藤田陽平、藤田知信、河上 裕、浜川裕之
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 樹状細胞におけるPD-Lsの制御とT細胞活性化能の増強 (2013)
  • Author(s): 田野智之、岡本正人、合田啓之、藤田陽平、中城公一、浜川裕之
  • Organizer: 第58回日本口腔外科学会総会・学術大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Prognostic impact of infiltration of M2 macrophages to tumor-invasive margin in patients with oral squamous cell carcinoma. (2013)
  • Author(s): Fujita Y, Okamoto M, Nakashiro K, Tano T, Goda H, Fujita T, Kawakami Y, Hamakawa H.
  • Organizer: 第 72 回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Fusions of TLR2/4-activated dendritic cells and whole tumor cells induce augmented cytotoxic T lymphocytes. (2013)
  • Author(s): Koido S, Shin K, Hayashi K, Ito M, Okamoto M, Ohkusa T, Homma S, Tajiri H.
  • Organizer: 第 72 回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Antitumor activity against human pancreatic cancer by Trastuzumab-Emtansine, a unique antibody-drug conjugate (2013)
  • Author(s): Kan S, Koido S, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Nagasaki E, Homma S.
  • Organizer: 第 72 回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 口腔扁平上皮癌患者における腫瘍微小環境下での interleuikin-8及び CD66b+好中球の予後への影響 (2013)
  • Author(s): 藤田陽平，岡本正人，中城公一，田野智之，合田啓之，藤田知信，河上 裕，浜川裕之
  • Organizer: 第 17 回日本がん免疫学会総会
  • Place of Presentation: ANAクラウンプラザホテル宇部
• [Presentation] 抗癌剤による樹状細胞の免疫抑制分子の制御とT細胞活性化の増強：PD-Lsの役割 (2013)
  • Author(s): 田野智之、岡本正人、合田啓之、藤田陽平、中城公一、浜川裕之
  • Organizer: 第 17 回日本がん免疫学会総会
  • Place of Presentation: ANAクラウンプラザホテル宇部
• [Presentation] 口腔白板症の癌化におけるNF-κBを介したM2マクロファージの関与 (2013)
  • Author(s): 原田耕志、Tarannum Ferdous、白石瑠里子、久野高博、岡本正人、上山吉哉
  • Organizer: 第 17 回日本がん免疫学会総会
  • Place of Presentation: ANAクラウンプラザホテル宇部
• [Presentation] 最先端のがん治療～樹状細胞を用いたがんワクチン～
  • Author(s): 岡本正人
  • Organizer: 八王子がん免疫細胞治療センター開設記念、第1回がん治療講演会
  • Place of Presentation: 京王プラザホテル八王子
  • Invited
• [Presentation] がんワクチン研究の現状と樹状細胞ワクチン療法の開発
  • Author(s): 岡本正人
  • Organizer: 琉球大学大学院・医学研究科 学術セミナー
  • Place of Presentation: 琉球大学医学部
  • Invited
• [Presentation] がんワクチンの研究・治験開発動向と臨床試験での試験デザイン・エンドポイント設定～樹状細胞がんワクチンを中心に～
  • Author(s): 岡本正人
  • Organizer: R&D支援センターセミナー
  • Place of Presentation: タイム24ビル、東京
  • Invited
• [Presentation] がんワクチン研究の現状と樹状細胞ワクチン療法の開発
  • Author(s): 岡本正人
  • Organizer: 第22回免疫細胞研究会
  • Place of Presentation: 光が丘会館、福島県立医科大学
  • Invited
• [Presentation] Dendritic cell-based vaccine for cancer
  • Author(s): Masato Okamoto
  • Organizer: Special Conference in Chung Shan Medical School
  • Place of Presentation: Chung Shan Medical School, Taichung, Taiwan
  • Invited
• [Book] Immunotherapy of Cancer: An Innovative Treatment Comes of Age (2016)
  • Author(s): Okamoto M
  • Total Pages: 358
  • Publisher: Springer Japan KK
• [Book] Immunotherapy of Cancer: An Innovative Treatment Comes of Age (2015)
  • Author(s): Masato Okamoto
  • Publisher: Springer