A new strategy of general anesthesia for oral and maxillofacial surgery based on the pharmacological control of tissue blood flow

• Project/Area Number: 25463147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: ICHINOHE Tatsuya 東京歯科大学, 歯学部, 教授 (40184626)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 組織血流量 / 口腔外科手術 / 麻酔薬 / 換気条件 / 相互作用

Outline of Final Research Achievements

Increases in oral tissue blood flow (OTBF) during inhalation anesthesia were not uniform among inhaled anesthetics and their concentrations (isoflurane > sevoflurane > desflurane). Although OTBF increased during administration of sevoflurane combined with nitrous oxide, OTBF remained decreased during concomitant administration of sevoflurane and remifentanil combined with nitrous oxide. Changes in OTBF during hyper/hypocapnia were smaller when remifentanil or dexmedetomidine was administered simultaneously with sevoflurane. It is suggested that redistribution of OTBF occurs during administration of remifentanil under sevoflurane anesthesia.

Research Products

• [Journal Article] Effect of changes in end-tidal carbon dioxide tension on oral tissue blood flow during dexmedetomidine infusion in rabbits (2015)
  • Author(s): Okada R, Matsuura N, Kasahara M, Ichinohe T
  • Journal Title: European Journal of Oral Sciences Volume: 123 Issue: 1 Pages: 24-29
  • DOI: 10.1111/eos.12162
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits (2015)
  • Author(s): Kasahara M, Ichinohe T, Okamoto S, Okada R, Kanbe H, Matsuura N
  • Journal Title: Journal of Anesthesia Volume: 29
  • Peer Reviewed / Open Access
• [Journal Article] Tissue blood flow during remifentanil infusion with carbon dioxide loading (2015)
  • Author(s): Kanbe H, Matsuura N, Kasahara M, Ichinohe T
  • Journal Title: Anesthesia Progress Volume: 62
  • Peer Reviewed / Open Access
• [Journal Article] Effects of volatile anesthetics on oral tissue blood flow: A comparison among isoflurane, sevoflurane and desflurane (2015)
  • Author(s): Okamoto S, Matsuura N, Ichinohe T
  • Journal Title: Journal of Oral and Maxillofacial Surgery Volume: 73
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 揮発性麻酔薬の濃度変化が口腔組織血流量に及ぼす影響
  • Author(s): 岡本聡太，一戸達也
  • Organizer: 第41回日本歯科麻酔学会学術集会
  • Place of Presentation: 新横浜国際ホテル（神奈川県横浜市）