A new strategy of general anesthesia for oral and maxillofacial surgery based on the pharmacological control of tissue blood flow
| Project/Area Number |
25463147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 組織血流量 / 口腔外科手術 / 麻酔薬 / 換気条件 / 相互作用 |
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| Outline of Final Research Achievements |
Increases in oral tissue blood flow (OTBF) during inhalation anesthesia were not uniform among inhaled anesthetics and their concentrations (isoflurane > sevoflurane > desflurane). Although OTBF increased during administration of sevoflurane combined with nitrous oxide, OTBF remained decreased during concomitant administration of sevoflurane and remifentanil combined with nitrous oxide. Changes in OTBF during hyper/hypocapnia were smaller when remifentanil or dexmedetomidine was administered simultaneously with sevoflurane. It is suggested that redistribution of OTBF occurs during administration of remifentanil under sevoflurane anesthesia.
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Report
(4 results)
Research Products
(5 results)
