| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Using a mouse model of transient ischemia/reperfusion injury, we investigated the threshold of ischemic periods. In addition, we examined the origin of injury-induced neural stem cells: iNSCs and their possible contribution to neurogenesis under such pathologic conditions. Although iNSCs were induced following not only lethal ischemic injury by more than 30-min ischemia but also non-lethal ischemic injury by 15-min ischemia, the numbers of iNSCs were fewer under 15-min ischemic conditions compared with those observed under 30-min ischemic conditions. We also found that iNSCs are likely derived from brain pericytes stimulated by ischemic insult and that they had an activity of producing neuronal cells.
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