Induction of neural stem cells and possible contribution to neurogenesis following transient brain ischemia
Project/Area Number |
25463159
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Osaka Dental University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MAEDA Mitsuyo 理化学研究所, CLST-JEOL連携センターマルチモダル微細構造解析ユニット, 客員主管研究員 (40122080)
MATSUYAMA Tomohiro 兵庫医科大学, 医学部, 教授 (10219529)
|
Research Collaborator |
NAKATA Masayo
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 神経幹細胞 / ペリサイト / 一過性脳虚血 / 再灌流傷害 / 血管周皮細胞 / pericyte / 再生医学 / 中枢神経 / 局所脳虚血 / 神経再生 |
Outline of Final Research Achievements |
Using a mouse model of transient ischemia/reperfusion injury, we investigated the threshold of ischemic periods. In addition, we examined the origin of injury-induced neural stem cells: iNSCs and their possible contribution to neurogenesis under such pathologic conditions. Although iNSCs were induced following not only lethal ischemic injury by more than 30-min ischemia but also non-lethal ischemic injury by 15-min ischemia, the numbers of iNSCs were fewer under 15-min ischemic conditions compared with those observed under 30-min ischemic conditions. We also found that iNSCs are likely derived from brain pericytes stimulated by ischemic insult and that they had an activity of producing neuronal cells.
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Report
(5 results)
Research Products
(25 results)
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[Book] 歯科衛生士テキスト 歯科麻酔学2013
Author(s)
小谷順一郎,佐久間泰司,足立了平(編)安東佳代子,今村佳樹,大草知佳,大西杏奈,加藤裕彦,金田一弘,釜田隆,河合峰雄,岸本直隆,木下郁恵,河見有恵,椎葉俊司,杉岡伸悟,大郷英里奈,田中沙里奈,豊永達宣,松下容子,真鍋庸三,百田義弘,山下智章,山本直子(著)
Total Pages
127
Publisher
学建書院
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