Analysis of expression pattern and function of micro-RNA in craniosynostosis
| Project/Area Number |
25463168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOBAYASHI YUKIHO 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (20596233)
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| Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Keiji 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20262206)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 頭蓋冠縫合部早期癒合症 / miRNA / アペール症候群 / 頭蓋冠冠状縫合部 / 歯科矯正学 / microRNA / 先天性疾患 / Craniosynostosis / FGFR / FGF |
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| Outline of Final Research Achievements |
We analyzed the expression pattern of miRNA in the calvarial sutures of Apert syndrome model mice (Ap mice) and the control mice (Ct mice). Ap mice showed higher expression of 19 kinds of miRNA and lower 5 kinds of miRNA significantly. Additionally, mmu-miR-182-5p and mmu-miR-206-3p significantly highly expressed in Ap mice by real-time PCR.
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Report
(4 results)
Research Products
(11 results)
