| Project/Area Number |
25502003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Reliable environmental measurement methods
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAGINAKA Jun 武庫川女子大学, 薬学部, 教授 (20164759)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 分子インプリントポリマー / 沈殿重合法 / 多段階膨潤重合法 / 分子認識 / 液体クロマトグラフィー / グルタチオン / ワルファリン / 安息香酸 / 分子インプリント法 / ＨＰＬＣ / カラム充填剤 |
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| Outline of Final Research Achievements |
First, a molecularly imprinted polymer (MIP) for a glutathione reduced form was successfully prepared by precipitation polymerization. Next, MIPs for warfarin (WF) and its chloro-substituted compound, coumachlor (CC), were prepared by multi-step swelling and polymerization. They were termed MIPWF and MIPCC, respectively. MIPCC could selectively recognize WF than MIPWF. Furthermore, MIPs for benzoic acid (BA) and its mono-, di-, tri-chloro derivatives were prepared by multi-step swelling and polymerization. MIPs for 3- and 4-chloro BAs, and 3,4- and 3,5-dichloro BAs could selectively recognize BA than the MIP for BA. These results suggest that the position and the number of substituent(s) for a template molecules could play an important role in the molecular recognition properties.
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