The basic investigation on the organ differences of fatty acid beta-oxidation system
| Project/Area Number |
25504016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Fujita Health University |
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Principal Investigator |
USUDA Nobuteru 藤田保健衛生大学, 医学部, 教授 (30135123)
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| Co-Investigator(Kenkyū-buntansha) |
FUKASAWA Motoaki 藤田保健衛生大学, 医学部, 助教 (70387728)
MORIYAMA Yohsuke 藤田保健衛生大学, 医学部, 助教 (00452532)
ATSUZAWA Kimie 藤田保健衛生大学, 医学部, 助教 (60387727)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Takashi 藤田保健衛生大学, 医学部, 客員教授 (80009935)
YAMAGUCHI Seiji 島根大学, 医学部, 教授 (60144044)
FUKAO Toshiyuki 岐阜大学, 医学部, 教授 (70260578)
TANAKA Masashi 地方独立行政法人東京都健康長寿医療センター, 研究所, 教授 (60155166)
SHIMOMURA Atsushi 北海道医療大学, 心理科学部, 教授 (50340237)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 栄養科学 / 脂肪酸β酸化系 / 臓器特異性 |
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| Outline of Final Research Achievements |
Hyperlipidemia is one of the causes of arteriosclerosis and fatty liver, which are risk factors of ischemic heart diseases and hepatic cirrhosis. The improvement of fatty acid metabolism can prevent and treat hyperlipidemia. All kinds of fatty acid are catabolized by mitochondrial fatty acid beta-oxidation system, which play central roles in energy production, however, needs further elucidation. Its physiological significance was investigated by studying the localization and the metabolic regulation by transcription factors PPARs, by employing whole body tissues and primary cultured cells from various organs.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain deficiency.2016
Author(s)
Kohda M, Mizuno Y, Hirata T, Yatsuka Y, Yamashita, Okuda A, Borna NN, Banshoya K, Ohnuma K, Suzuki T, Nagao A, Maehata H, Matsuda F, Higasa K, Nagasaki M, Yasuda J, Yamamoto M, Fushimi T, Shimura M, Kaiho-Ichimoto K, Harashima H, Yamazaki T, Mori M, Murayama K, Ohtake A, Okazaki Y.
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Journal Title
PLoS Genetics:
Volume: 12(1)
Issue: 1
Pages: e1005679-e1005679
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation.2014
Author(s)
Fukao T, Akiba K, Goto M, Kuwayama N, Morita M, Hori T, Aoyama Y, Venkatesan R, Wierenga R, Moriyama Y, Hashimoto T, Usuda N, Murayama K, Ohtake A, Hasegawa Y, ShigematsuY, Hasegawa Y.
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Journal Title
J Hum Genet
Volume: 59
Issue: 11
Pages: 609-614
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 施灸の報酬特性に関する研究2015
Author(s)
深澤元晶、木下雄貴、中井さち子、渡仲三、臼田信光
Organizer
第64回全日本鍼灸学会学術大会
Place of Presentation
福島県郡山市ビッグパレットふくしま
Year and Date
2015-05-22
Related Report
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