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Nutritional optimization for regenerative radiation emergency medicine

Research Project

Project/Area Number 25504022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

Michikawa Yuichi  国立研究開発法人放射線医学総合研究所, 緊急被ばく医療研究センター, 主任研究員 (20360688)

Co-Investigator(Kenkyū-buntansha) OHNISHI Junji  東京家政大学, 家政学部, 准教授 (40261276)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords放射線 / 被ばく / 再生医療 / 幹細胞 / 栄養 / 消化管
Outline of Final Research Achievements

This study has an aim to maximize efficiency of regenerative medical techniques for radiation emergency by maximizing nutritional components. Four nutritional factors, 1) Marine Crystal Mineral, 2) DietGel, 3) Ketogenic diet, and 4) Elementary liquid diet were orally treated to severely irradiated mice, respectively. Among them, the elementary liquid diet showed improvement in reducing kinetics of body weight loss after 4 days post irradiation and in survival period. Further studies will be conducted at elsewhere to investigate effect of the elementary liquid diet on transplantation efficiency of stem cells and of their function in rescuing severely irradiated mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 Other

All Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Presentation] Updating radiation emergency medicine by stem cell technologies2015

    • Author(s)
      道川祐市
    • Organizer
      中国放射線医学研究所セミナー
    • Place of Presentation
      放射線医学研究所(中国、天津)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Construction of Secure Medical Base of Radiation Emergency2015

    • Author(s)
      道川祐市
    • Organizer
      International Symposium on Space Technology and Science
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-07-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Seamless quantitative assessments from whole body to cellular level for high dose radiation-induced mouse intestinal injury/rescue.2015

    • Author(s)
      道川祐市
    • Organizer
      International Congress on Radiation Research
    • Place of Presentation
      京都国際会館(京都府、京都市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス腸管における放射線障害/再生医療の3次元組織学的解析2015

    • Author(s)
      道川祐市
    • Organizer
      日本再生医療学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 月・火星における緊急被ばく医療2015

    • Author(s)
      道川祐市
    • Organizer
      月と火星の縦孔・地下空洞研究会
    • Place of Presentation
      JAXA相模原研究所
    • Year and Date
      2015-03-03
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス間葉系幹細胞の皮下移植による放射線誘発白毛化の抑制

    • Author(s)
      道川祐市
    • Organizer
      日本再生医療学会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] 新しい放射線被ばく医療技術の開発現状と、宇宙医学への適応

    • Author(s)
      道川祐市
    • Organizer
      月と火星の縦孔溶岩チューブ研究会
    • Place of Presentation
      富士河口湖中央公民館
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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