| Project/Area Number |
25504022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
Michikawa Yuichi 国立研究開発法人放射線医学総合研究所, 緊急被ばく医療研究センター, 主任研究員 (20360688)
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI Junji 東京家政大学, 家政学部, 准教授 (40261276)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 放射線 / 被ばく / 再生医療 / 幹細胞 / 栄養 / 消化管 |
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| Outline of Final Research Achievements |
This study has an aim to maximize efficiency of regenerative medical techniques for radiation emergency by maximizing nutritional components. Four nutritional factors, 1) Marine Crystal Mineral, 2) DietGel, 3) Ketogenic diet, and 4) Elementary liquid diet were orally treated to severely irradiated mice, respectively. Among them, the elementary liquid diet showed improvement in reducing kinetics of body weight loss after 4 days post irradiation and in survival period. Further studies will be conducted at elsewhere to investigate effect of the elementary liquid diet on transplantation efficiency of stem cells and of their function in rescuing severely irradiated mice.
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