| Project/Area Number |
25540014
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Statistical science
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| Research Institution | Chuo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SERA kouichirou 岩手医科大学, 医学部, 教授 (00230855)
YAMADA Tomomi 大阪大学, 医学部付属病院, 准教授 (60363371)
MAKIE Toshio 国立循環器病研究センター, その他部局当, 研究員 (80435891)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 毛髪ミネラル / 微量元素 / 個人内分散 / 測定誤差 / PIXE / アトピー / 統計解析 / 疫学応用 / 個人間分散 / 物理測定誤差 / 疫学利用 / リスク解析 / 数理モデル / True-equivalent sample / SIMEX |
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| Outline of Final Research Achievements |
The object of the study is to develop a method to solve the statistical difficulties associated with the mineral amounts in hairs measured by PIXE method. We collected two samples from each of 206 6-years old children from which we obtained two independent measurements for each child. For 29 out of 32 minerals, it was confirmed that the differences between the two measurements for the subjects approximately follow a normal distribution, indicating that the errors in hair mineral measurements are random, and therefore the mean of the two measurements are valid. Further, the mean of the two measurements approximately follows a known parametric distribution. The results will enhance the use of hair minerals in medicine and epidemiology.
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