| Project/Area Number |
25560196
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
ARAKI Tsutomu 大阪大学, 基礎工学研究科, 教授 (50136214)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Shuichiro 大阪大学, 基礎工学研究科, 助教 (40362644)
MIURA Jiro 大阪大学, 歯学部附属病院, 助教 (70437387)
三浦 治郎 大阪大学, 歯学部附属病院, 助教 (70437383)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 象牙質 / 老化 / 糖化 / メイラード反応 / コラーゲン / 蛍光 / 押し込み試験 |
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| Outline of Final Research Achievements |
This project revealed the effect of glycation, which causes aging of biological tissue, to teeth. The results of imunostaining of advanced glycation endproducts (AGEs) showed that accumulation of AGEs in dentine increased with aging, especially around dental tubule. Moreover, hardness of demineralized dentin increased with aging. These results indicate that teeth aging is related to glycation progress, and AGEs cross-linkage to collage in dentine affects mechanical property of teeth. To evaluate the teeth aging, fluorometry is effective because fluorescent AGEs accumulation in dentine was confirmed, and fluorescent lifetime of dentine decreased with the glycation progress.
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