| Project/Area Number |
25560213
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YADA Toyotaka 川崎医科大学, 医用工学, 講師 (00210279)
NAKAMOTO Hiroshi 川崎医科大学, 医用工学, 助教 (10299183)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インスリン / 血糖値調整 / ICU / 血糖値 / インスリン投与 / 血糖動態 / 回帰モデル / 血糖コントロール / 血行動態 / ＩＣＵ |
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| Outline of Final Research Achievements |
It is important to maintain blood glucose levels within an appropriate range in a treatment of severe patients. The intensive insulin therapy is known to be effective for the treatment of these patients; however, it is required to frequently monitor blood glucose levels and to inject proper amounts of insulin appropriate timings. Recently, a feedback control system for insulin injection has been developed by using the algorithm based on a classic control theory.
In this study, we have developed a noble algorithm based on a multivariable self-regression model for insulin administration. It was confirmed that the new system demonstrated satisfying performance by simulation experiments using a simulator for blood glucose dynamics.
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