| Project/Area Number |
25560258
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
KUROKI Hiroshi 京都大学, 医学(系)研究科(研究院), 教授 (20170110)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 超音波 / 低出力 / パルス / 関節軟骨 / 変形性関節症 |
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| Outline of Final Research Achievements |
Low-Intensity Pulsed Ultrasound (LIPUS) has applied for the cultured chondrocyte supplemented with IL-1beta. MMP13 mRNA was up-regulated by IL-1beta, however, the up-regulation was in part repressed by LIPUS exposure. The repressive effect of LIPUS on MMP13 was higher in the higher LIPUS intensity. An osteochondral defect was created at femoral groove of rat, and then LIPUS exposure was performed. LIPUS exposure at the osteochondral defect was more promoted the repair than the sham exposure. Therefore, it was suggested that LIPUS might repress the induction of MMP13 mRNA expression induced by IL-1beta in an intensity-dependent manner, and also suggested that LIPUS might promote the articular cartilage repair on the animal model of the osteochondral defect.
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