Exploring a new approach to accelerate fracture healing based on the fracture after spinal cord injuries

• Project/Area Number: 25560260
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kobe University
• Principal Investigator: MORIYAMA HIDEKI 神戸大学, 保健学研究科, 教授 (10438111)
• Co-Investigator(Kenkyū-buntansha): MIURA Yasushi 神戸大学, 大学院保健学研究科, 准教授 (60346244)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 骨折 / 脊髄損傷

Outline of Final Research Achievements

Several clinical studies have been demonstrated that the fracture associated with spinal cord injuries tends to heal quickly. Little is known about the process of restoration to the bone's original shape and structure from the fractures with spinal cord injuries. Therefore, in the present study, we sought to determine whether spinal cord injuries resulted in accelerated fracture healing and to characterize the process of accelerated fracture healing with spinal cord injuries. As a result, spinal cord injuries accelerated fracture healing by approximately 40%, when compared with normal fracture healing. The accelerated fracture healing with spinal cord injuries may be due to the change in ossification from endochondral to intramembranous ossification. In addition, we determined which the factor is most responsible for the findings. The factor most responsible for the accelerated fracture healing was originated from the muscle hypertonia after spinal cord injuries.

Research Products

• [Presentation] Effects of spinal cord injury on fracture healing in rats (2015)
  • Author(s): Sakitani N, Watanabe D, Iwasawa H, Nomura M, Watanabe K, Takano S, Moriyama H
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2015
  • Place of Presentation: Singapore
  • Year and Date: 2015-05-01
  • Int'l Joint Research
• [Presentation] Spinal cord injury leads to region specific tidemark advancement in articular cartilage of the knee joint in rats (2015)
  • Author(s): Nomura M, Iwasawa H, Sakitani N, Watanabe K, Watanabe D, Takano S, Moriyama H
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2015
  • Place of Presentation: Singapore
  • Year and Date: 2015-05-01
  • Int'l Joint Research
• [Presentation] Changes of muscular and articular factors in joint contracture after spinal cord injury in rats (2015)
  • Author(s): Watanabe K, Iwasawa H, Sakitani N, Nomura M, Watanabe D, Moriyama H
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2015
  • Place of Presentation: Singapore
  • Year and Date: 2015-05-01
  • Int'l Joint Research
• [Presentation] The effects of heat, icing, and stretching on knee joint capsule in rat contracture model of spinal cord injury (2015)
  • Author(s): Iwasawa H, Sakitani N, Nomura M, Watanabe D, Watanabe K, Takano S, Moriyama H
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2015
  • Place of Presentation: Singapore
  • Year and Date: 2015-05-01
  • Int'l Joint Research
• [Presentation] Comparison of thermal and cold therapy combined with stretching for correction of contracture after spinal cord injury in rats (2015)
  • Author(s): Moriyama H, Atsuji H, Usumoto Y, Ozawa J, Kito N, Tanaka R, Kanemura N, Deie M
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2015
  • Place of Presentation: Singapore
  • Year and Date: 2015-05-01
  • Int'l Joint Research
• [Presentation] 骨折の治癒過程は脊髄損傷により改変される (2014)
  • Author(s): 崎谷直義, 岩澤裕之, 野村将人, 渡辺昴介, 渡辺大地, 高野祥子, 森山英樹
  • Organizer: 兵庫県骨・カルシウムを語る会
  • Place of Presentation: ANAクラウンプラザホテル神戸（兵庫県・神戸市）
  • Year and Date: 2014-11-13
• [Book] 運動器疾患の病態と理学療法 (2015)
  • Author(s): 森山英樹, 木藤伸宏, 奈良勲
  • Total Pages: 316
  • Publisher: 医歯薬出版株式会社