Roles of skeletal muscle in whole body homeostasis
| Project/Area Number |
25560338
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
ONO Yusuke 長崎大学, 原爆後障害医療研究所, 講師 (60601119)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 骨格筋 / 生体恒常性 / がんカヘキシア / 筋萎縮 / 筋可塑性 / 筋由来分泌因子 / 筋肥大 / マイオカイン / サテライト細胞 |
|---|
| Outline of Final Research Achievements |
We examined roles of skeletal muscle in whole body homeostasis using mouse models including cancer cachexia. Cancer cachexia was induced by injection of C26 mouse colon cancer cells. Several genes involved in regulating lipid metabolism in the body were abnormally expressed in atrophic muscles in the cancer cachexia model. We next investigated the function of μ-Crystallin (Crym) in skeletal muscle as well as whole body homeostasis. Crym was preferentially expressed in skeletal muscle. Crym-knockout mice exhibited an increase in grip strength and high intensity running ability. Genetic inactivation of Crym also improved high-fat-diet-induced metabolic abnormalities in vivo. These results indicate that the alteration in quality and mass of muscles potentially influences whole body homeostasis.
|
Report
(4 results)
Research Products
(26 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 新骨格筋生物学2015
Author(s)
小野悠介
Organizer
立命館大学・運動生理・生化学特論
Place of Presentation
立命館大学（滋賀・草津市）
Year and Date
2015-05-21
Related Report
Invited
-
-
-
-
-
[Presentation] 骨筋可塑性の分子制御2014
Author(s)
小野悠介
Organizer
第22回日本運動生理学会
Place of Presentation
川崎医療福祉大学（倉敷）
Year and Date
2014-07-19
Related Report
Invited
-
-
-
-
-
-
-
