| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In general, moderate exercise enhances immune system. However, hard exercise, such as a triathlon, is often accompanied by the impairment of immune system. During the time of immune impairment, bacteria or virus are allowed to infect our body easily. In other word, a window is opened for a virus by hard exercise. Therefore, this model is referred to as the open window theory. Using acute and chronic muscle-injured model, we found that muscle regeneration suppresses LPS-mediated inflammatory cytokine expression. We could deny the effect of stress, because stress maker was not increased in these models.
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