Identification of muscle derived immune suppressive factor
Project/Area Number |
25560367
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied health science
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Research Institution | Osaka University |
Principal Investigator |
FUKADA So-ichiro 大阪大学, 薬学研究科(研究院), 研究員 (20432445)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 骨格筋 / 筋傷害 / 炎症性サイトカイン / 筋ジストロフィー / 筋損傷 |
Outline of Final Research Achievements |
In general, moderate exercise enhances immune system. However, hard exercise, such as a triathlon, is often accompanied by the impairment of immune system. During the time of immune impairment, bacteria or virus are allowed to infect our body easily. In other word, a window is opened for a virus by hard exercise. Therefore, this model is referred to as the open window theory. Using acute and chronic muscle-injured model, we found that muscle regeneration suppresses LPS-mediated inflammatory cytokine expression. We could deny the effect of stress, because stress maker was not increased in these models.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration2015
Author(s)
Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S.
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Journal Title
Development
Volume: 142
Pages: 51-61
Related Report
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