• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of muscle derived immune suppressive factor

Research Project

Project/Area Number 25560367
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionOsaka University

Principal Investigator

FUKADA So-ichiro  大阪大学, 薬学研究科(研究院), 研究員 (20432445)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨格筋 / 筋傷害 / 炎症性サイトカイン / 筋ジストロフィー / 筋損傷
Outline of Final Research Achievements

In general, moderate exercise enhances immune system. However, hard exercise, such as a triathlon, is often accompanied by the impairment of immune system. During the time of immune impairment, bacteria or virus are allowed to infect our body easily. In other word, a window is opened for a virus by hard exercise. Therefore, this model is referred to as the open window theory. Using acute and chronic muscle-injured model, we found that muscle regeneration suppresses LPS-mediated inflammatory cytokine expression. We could deny the effect of stress, because stress maker was not increased in these models.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (3 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] Fibrogenic cell plasticity blunts tissue regeneration and aggravates muscular dystrophy [掲載確定]2015

    • Author(s)
      Pessina P, Kharras Y, Jardi M, Fukada S, Serrano S, Perdiguero E, Munoz-Canovas P
    • Journal Title

      Stem Cell Reports

      Volume: in press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Pro-IGF-II ameliorates age-related inefficient regenerative response by orchestrating self-reinforcement mechanism of muscle regeneration. [掲載確定]2015

    • Author(s)
      Ikemoto-Uezumi M, Uezumi A, Tsuchida K, Fukada S, Yamamoto H, Yamamoto N, Shiomi K, Hashimoto N
    • Journal Title

      Stem Cells

      Volume: in press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration2015

    • Author(s)
      Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S.
    • Journal Title

      Development

      Volume: 142 Pages: 51-61

    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨格筋幹細胞の基礎研究から 応用研究にむけて2014

    • Author(s)
      深田宗一朗
    • Organizer
      第14回 CMBR
    • Place of Presentation
      静岡、ラフォーレ修善寺ホテル
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 筋骨格系の共通制御因子としてのカルシトニン受容体の可能性2014

    • Author(s)
      深田宗一朗
    • Organizer
      第29回 日本整形外科学会基礎学術集会、シンポジウム
    • Place of Presentation
      鹿児島 城山観光ホテル
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
    • Invited

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi