| Project/Area Number |
25560403
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
HORI Yuichiro 大阪大学, 工学(系)研究科(研究院), 助教 (00444563)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 光受容タンパク質 / PYP / 光構造変換 / 光構造変換分子 / 光照射 |
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| Outline of Final Research Achievements |
Caged compounds are useful functional molecules that can control its bioactivity. On the other hand, there are some problems that some of the compounds require UV irradiation or undergoes photodegradation during syntheses. Herein, to overcome these problems, we creat a novel photoconversion system using a photoreceptor protein, PYP, and its newly found ligand, 2,4-dihydroxycinnamic acid. In this system, the ligand binds to PYP and induces photoisomerization and the subsequent structural change upon irradiation with visible light.
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