Measurement of rheology of water surrounding molecular assembly toward revealing the water-cooperated chemical phenomena in life
| Project/Area Number |
25620002
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
TAKEDA Sadamu 北海道大学, 大学院理学研究院, 教授 (00155011)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 水 / 分子集合体 / 核磁気共鳴 / 緩和測定 / 分子運動 / 水和水 / NMR / 動的核分極 / 流動性 / ナノ空間 / ESR / 巨視的構造変化 / 協同効果 / 超分子機械 / ＮＭＲ / ＥＳＲ / オーバーハウザー効果 |
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| Outline of Final Research Achievements |
As the main component of living cells is water, life phenomena are presented in water. Water surrounds cellular membranes, peptides, and other biomolecules. The surrounding water has different characteristics than general water, and the characteristics are related to the brilliant functions of biomolecules. Therefore, a development of a characteristic water analysis is required to reveal the biological phenomena.
Selective analysis of specific water in bulk water is difficult. One potent method is the Overhauser dynamic nuclear polarization nuclear magnetic resonance (DNP-NMR). For our project, we equipped an instrument to measure the water molecules using DNP-NMR. We also used organic synthetic techniques to prepare artificial molecular assemblies, and measured the water surrounding the assemblies. In perspective, it is required to improve the accuracy of quantitative discussions for rheology of water by merging the theoretical approach with further measurements.
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Report
(3 results)
Research Products
(21 results)
