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Basic Research for Development of Aasymmetric Synthesis by the use of Nanotechnology

Research Project

Project/Area Number 25620005
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical chemistry
Research InstitutionTohoku University

Principal Investigator

TAKAOKA Tsuyoshi  東北大学, 多元物質科学研究所, 講師 (90261479)

Co-Investigator(Kenkyū-buntansha) KITAYAMA Takashi  近畿大学, 農学部, 教授 (00278730)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords表面 / 不斉反応 / 分子線 / 合成反応 / 走査型トンネル顕微鏡 / 不斉合成 / 絶不斉不合成
Outline of Final Research Achievements

Many organic compounds are currently synthesized. Each compound contains a carbon atom to which four different functional group is bonded so that not only the organic compound of interest but structural mirror images of the compound are will also be synthesized. Therefore, we attempted to develop new methods for synthesizing only the organic compound of interest by utilizing the nanotechnology and molecular-beam technology that controls the speed of the molecules of the reaction of the starting materials. In the results of this study, it was found to be sufficiently control the speed of the reaction molecules. In addition, it becomes possible to detect molecules that were the products in the reaction. We think that it is possible to reach the stage of applying the new approach.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) (of which Invited: 1 results)

  • [Journal Article] Locomotor-reducing effects and structural characteristics of inhaled zerumbone and tetrahydrozerumbone derivatives2014

    • Author(s)
      K. Ogawa, T. Miyoshi, T. Kitayama, and M. Ito
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 37 Pages: 1559-1563

    • NAID

      130004684793

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric synthesis of enantiomerically pure zingerols by lipase-catalyzed transesterification and efficient synthesis of their analogues2013

    • Author(s)
      T. Kitayama, S. Isomori, K. Nakamura
    • Journal Title

      Tetrahedron Asymmetry

      Volume: 24 Issue: 11 Pages: 621-627

    • DOI

      10.1016/j.tetasy.2013.04.013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Piperine analogues in a hydrophobic fraction from Piper ribersoides (Piperaceae) and its insect antifeedant activity2013

    • Author(s)
      T. Kitayama, K. Yasuda, T. Kihara, S. Sawada, M. Ito, H. Fukumoto, M. Morimoto
    • Journal Title

      Applied Entomology and Zoology

      Volume: 48 Issue: 4 Pages: 455-459

    • DOI

      10.1007/s13355-013-0204-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sedative effects of inhaled benzylacetone and structural features contributing to its activity2013

    • Author(s)
      T. Miyoshi, S. Isomori, T. Kitayama, F. Yamashita, M. Ito
    • Journal Title

      BIOLOGICAL & PHARMACEUTICAL BULLETIN

      Volume: 36 Pages: 1474-1481

    • NAID

      130003361519

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel synthesis of zerumbone-pendant derivatives and their biological activity2013

    • Author(s)
      Takashi Kitayama, Maki Nakahira, Kae Yamasaki, Hiromi Inoue, Chika Imada, Yuji Yonekura, Masataka Awata, Hikaru Takaya, Yasushi Kawai, Kohta Oknishi, and Akira Murakami
    • Journal Title

      Tetrahedron

      Volume: VOL.69 Issue: 47 Pages: 10152-10160

    • DOI

      10.1016/j.tet.2013.09.026

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 分子線による表面吸着分子の衝突誘起移動2014

    • Author(s)
      高岡 毅,米田忠弘,
    • Organizer
      第 75 回応用物理学会秋季学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Valerena-4,7(11)-dieneの合成研究2013

    • Author(s)
      白井貴士・妻形博紀・伊豆友香子・北山隆
    • Organizer
      第57回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      さいたま市 埼玉大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Synthetic study of enantiomerically pure valerena-4,7(11)-diene with potent sedative activity and its antipode2013

    • Author(s)
      伊豆友香子・白井貴士・妻形博紀・北山隆
    • Organizer
      14th Tetrahedron Symposium - Asian Edition
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2013 Research-status Report
  • [Presentation] Synthetic study of zerumbone derivatives using Favorskii rearrangement2013

    • Author(s)
      福島美幸・井副壮・高橋一生・北山隆
    • Organizer
      14th Tetrahedron Symposium - Asian Edition
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2013 Research-status Report
  • [Presentation] Synthesis of enantiomerically pure allene-zerumbone with twelve membered ring2013

    • Author(s)
      亀尾昌樹・巽大明・北山隆
    • Organizer
      14th Tetrahedron Symposium - Asian Edition
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2013 Research-status Report
  • [Presentation] Fundamental reaction activity of zerumbone with conjugated system in the eleven-membered ring structure2013

    • Author(s)
      山本智恵子・都築輝考・北山隆
    • Organizer
      14th Tetrahedron Symposium - Asian Edition
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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