Development of New Synthetic Reactions Based on Generation of Organometallic Species of Unstable Valency

Research Project

Project/Area Number	25620034
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Organic chemistry
Research Institution	Tokyo University of Science, Yamaguchi
Principal Investigator	Hojo Makoto 山口東京理科大学, 工学部, 教授 (50229150)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	Rieke亜鉛 / 還元 / 不飽和結合 / 還元的二量化 / 還元的環化 / α,β-不飽和カルボニル化合物
Outline of Final Research Achievements	It was found that reductive dimerization of α,β-unsaturated esters at β-position took place in Rieke zinc Zn-LDBB (lithium di-tert-butylbiphenylide) system to afford the corresponding adipates. Reductive cyclization reactions of bis-enoates, keto-enoates, and keto-alkenes were also found in the Zn-LDBB system. These reactions are thought to proceed through chain mechanism based on high one-electron reducing ability of Rieke zinc toward radical anion generated from substrate.

Report

(4 results)