| Project/Area Number |
25620127
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
TAKI Masumi 電気通信大学, 情報理工学(系)研究科, 准教授 (70362952)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 10BASEd-T / T7ファージ / ファージディスプレイ / 人工分子コア / 分子進化 / ファーマコフォア / ライブラリー / 触媒 / サリチル酸 / 人工分子進化 |
|---|
| Outline of Final Research Achievements |
We have demonstrated generation of a novel pharmacophore from artificial drug-like core structure (i.e. salicylic acid) by optimization of the surrounding peptide sequence. The point is that the drug-like core structure is never known to bind to a target protein. That is entirely different from improvement of a known drug structure by similar in vitro selection. We hope that computer assisted de novo designing, data mining from broad public databases, and/or docking simulation of the small drug-like core molecule followed by optimization of its surroundings by peptide via the 10BASEd-T would be a general technology for drug discovery. This has been published in an open-access journal of Molecules, 19, 2481-2496 (2014).
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