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Prediction of Thrombus Development and Antithrombotic Therapy Plan Based on Biomechanics

Research Project

Project/Area Number 25630046
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Fluid engineering
Research InstitutionChiba University

Principal Investigator

TSUBOTA Ken-ichi  千葉大学, 工学(系)研究科(研究院), 准教授 (10344045)

Co-Investigator(Renkei-kenkyūsha) LIU Hao  千葉大学, 大学院工学研究科, 教授 (40303698)
HANEISHI Hideaki  千葉大学, 大学院工学研究科, 教授 (20228521)
Research Collaborator SUGHIMOTO Koichi  The Royal Children's Hospital, Melbourne, 医師
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsバイオメカニクス / 血流 / 血栓 / 単心室 / 粒子法 / 計算機シミュレーション / 予測モデル / 薬効評価
Outline of Final Research Achievements

A biomechanics simulation method of thrombus formation in a cardiovascular system was developed considering the influence of blood flow. The atriopulmonary connection (APC) and the total cavopulmonary connection (TCPC) were considered as an operation for single ventricle. As a result of simulation, blood flow and the resulting thrombus formation were different between APC and TCPC. A simulation model of medicinal effects of antithrombotic drug was developed to investigate effects of an amount and administration timing on the antithrombotic. On the other hand, mechanism of motion and deformation of red and white blood cells was investigated toward development of high precision biomechanics model for thrombus formation.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (22 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (17 results) (of which Invited: 4 results)

  • [Journal Article] Applications of Computational Models to Better Understand Microvascular Remodeling: A Focus on Biomechanical Integration across Scales2015

    • Author(s)
      Murfee, W. L., Sweat, R. S., Tsubota, K., Mac Gabhann, F., Khismatullin, D., and Peirce, S. M.
    • Journal Title

      Interface Focus

      Volume: 5 Issue: 2 Pages: 20140077-20140077

    • DOI

      10.1098/rsfs.2014.0077

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Short note on the bending models for a membrane in capsule mechanics: Comparison between continuum and discrete models2014

    • Author(s)
      Tsubota, K.
    • Journal Title

      Journal of Computational Physics

      Volume: 277 Pages: 320-328

    • DOI

      10.1016/j.jcp.2014.08.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Elastic behavior of a red blood cell with the membrane‘s nonuniform natural state: Equilibrium shape, motion transition under shear flow, and elongation during tank- treading motion2013

    • Author(s)
      K. Tusbota, S. Wada, H. Liu
    • Journal Title

      Biomechanics and Modeling in Mechanobiology

      Volume: - Issue: 4 Pages: 735-746

    • DOI

      10.1007/s10237-013-0530-z

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blood flow dynamic improvement with aneurysm repair detected by a patient-specific model of multiple aortic aneurysms2013

    • Author(s)
      Sughimoto, K., Takahara, Y., Mogi, K., Yamazaki, K., Tsubota, K., Liang, F. and Liu, H.
    • Journal Title

      Heart and Vessels

      Volume: in press Issue: 3 Pages: 404-412

    • DOI

      10.1007/s00380-013-0381-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional modulation of cortical plasticity during pseudopodial protrusion of mouse leukocytse2013

    • Author(s)
      H. Miyoshi, K. Tsubota, T. Hoyano, T. Adachi, H. Liu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: - Issue: 4 Pages: 594-599

    • DOI

      10.1016/j.bbrc.2013.08.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] せん断速度に応じた動脈血栓の粒子法シミュレーション2015

    • Author(s)
      小須田雅貴,坪田健一,劉浩
    • Organizer
      日本機械学会第27回バイオエンジニアリング講演会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] せん断流れ場における運動と変形に基づく赤血球膜の面粘弾性特性の推定2015

    • Author(s)
      坪田健一
    • Organizer
      日本機械学会第27回バイオエンジニアリング講演会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 微小流路における血栓形成過程2014

    • Author(s)
      小池一輝,坪田健一,劉浩
    • Organizer
      日本機械学会第25回バイオフロンティア講演会
    • Place of Presentation
      鳥取市
    • Year and Date
      2014-10-03 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 薬効を考慮した血栓形成・溶解の粒子法シミュレーション2014

    • Author(s)
      遠藤豊,坪田健一,杉本晃一,劉浩
    • Organizer
      日本機械学会第25回バイオフロンティア講演会
    • Place of Presentation
      鳥取市
    • Year and Date
      2014-10-03 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] せん断速度に応じた血栓形成の粒子法シミュレーション2014

    • Author(s)
      小須田雅貴,坪田健一,劉浩
    • Organizer
      日本機械学会2014年度年次大会
    • Place of Presentation
      東京都
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Computer Simulation of Thrombus Formation in Single Ventricle Using Particle Method2014

    • Author(s)
      Tsubota, K.
    • Organizer
      11th World Congress on Computational Mechanics (WCCM XI)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biomechanics simulation of passive and active motions of blood cells2014

    • Author(s)
      Tsubota, K.
    • Organizer
      7th World Congress of Biomechanics (WCB2014)
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 赤血球の形状記憶の力学シミュレーション2014

    • Author(s)
      坪田健一
    • Organizer
      第19回計算工学講演会
    • Place of Presentation
      広島市
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Computer Simulation of Cellular Shape Based on Mechanical Deformation2014

    • Author(s)
      Tsubota, K.
    • Organizer
      Computational Engineering and Science for Safety and Environmental Problems (COMPSAFE2014)
    • Place of Presentation
      仙台市
    • Year and Date
      2014-04-13 – 2014-04-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Particle method computer simulation of thrombus formation in single ventricle2014

    • Author(s)
      Tsubota, K.
    • Organizer
      Advances in Computational Fluid–Structure Interaction and Flow Simulation
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] フォンタン手術後の血栓形成の二次元粒子法シミュレーション(臨床データとの比較)2014

    • Author(s)
      岡内一輝,坪田健一,杉本晃一,劉浩
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] 粒子法を用いた血栓形成のバイオメカニクスシミュレーション(モデルパラメタの影響)2014

    • Author(s)
      小須田雅貴,坪田健一,劉浩
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] 坪田健一,劉浩2014

    • Author(s)
      膜の面外曲げ弾性モデルに応じたカプセルの変形
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] 三好洋美,坪田健一,保屋野貴匡,安達泰治,劉浩2014

    • Author(s)
      マウス白血球の移動運動における細胞表層の力学特性
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] 単心室症における血栓形成の二次元粒子法シミュレーション2013

    • Author(s)
      坪田健一
    • Organizer
      日本機械学会2013年度年次大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Computer Simulation of Motion and Deformation of Red Blood Cell Under Shear Flow Considering Membrane’s Natural State2013

    • Author(s)
      Tsubota, K. and Liu, H.
    • Organizer
      5th International Conference on Computational Methods for Coupled Problems in Science and Engineering – Coupled Problems 2013
    • Place of Presentation
      Ibiza, Spain
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 単心室症における血栓形成の二次元粒子法シミュレーション2013

    • Author(s)
      岡内一輝,坪田健一,杉本晃一,劉浩
    • Organizer
      第17回計算工学講演会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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