Prediction of Thrombus Development and Antithrombotic Therapy Plan Based on Biomechanics
| Project/Area Number |
25630046
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fluid engineering
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| Research Institution | Chiba University |
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Principal Investigator |
TSUBOTA Ken-ichi 千葉大学, 工学(系)研究科(研究院), 准教授 (10344045)
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| Co-Investigator(Renkei-kenkyūsha) |
LIU Hao 千葉大学, 大学院工学研究科, 教授 (40303698)
HANEISHI Hideaki 千葉大学, 大学院工学研究科, 教授 (20228521)
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| Research Collaborator |
SUGHIMOTO Koichi The Royal Children's Hospital, Melbourne, 医師
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バイオメカニクス / 血流 / 血栓 / 単心室 / 粒子法 / 計算機シミュレーション / 予測モデル / 薬効評価 |
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| Outline of Final Research Achievements |
A biomechanics simulation method of thrombus formation in a cardiovascular system was developed considering the influence of blood flow. The atriopulmonary connection (APC) and the total cavopulmonary connection (TCPC) were considered as an operation for single ventricle. As a result of simulation, blood flow and the resulting thrombus formation were different between APC and TCPC. A simulation model of medicinal effects of antithrombotic drug was developed to investigate effects of an amount and administration timing on the antithrombotic. On the other hand, mechanism of motion and deformation of red and white blood cells was investigated toward development of high precision biomechanics model for thrombus formation.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Applications of Computational Models to Better Understand Microvascular Remodeling: A Focus on Biomechanical Integration across Scales2015
Author(s)
Murfee, W. L., Sweat, R. S., Tsubota, K., Mac Gabhann, F., Khismatullin, D., and Peirce, S. M.
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Journal Title
Interface Focus
Volume: 5
Issue: 2
Pages: 20140077-20140077
DOI
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Blood flow dynamic improvement with aneurysm repair detected by a patient-specific model of multiple aortic aneurysms2013
Author(s)
Sughimoto, K., Takahara, Y., Mogi, K., Yamazaki, K., Tsubota, K., Liang, F. and Liu, H.
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Journal Title
Heart and Vessels
Volume: in press
Issue: 3
Pages: 404-412
DOI
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Peer Reviewed
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[Presentation] 坪田健一，劉浩2014
Author(s)
膜の面外曲げ弾性モデルに応じたカプセルの変形
Organizer
日本機械学会第26回バイオエンジニアリング講演会
Place of Presentation
仙台市
Related Report
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