| Project/Area Number |
25640001
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Hokkaido University |
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Principal Investigator |
KAMIYA Haruyuki 北海道大学, 医学(系)研究科(研究院), 教授 (10194979)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳・神経 / 神経科学 / 生理学 / 薬理学 / シグナル伝達 |
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| Outline of Final Research Achievements |
In this study, we aimed at elucidating the roles of two modes of presynaptic gap junction, i.e. axo-axonal gap junction coupling and axo-dendritic gap junction coupling at the hippocampal mossy fiber synapses, which have been suggested to exsist on the basis of morphological analysis using connexin 36 immunoreactivity. Application of a gap junction blocker, meclofenamic acid, reversibly suppressed the excitatory postsynaptic potentials at the mossy fiber-CA3 synapse, supporting the possibility that the hippocampal mossy fiber synapse might be a unique mixed synapse composed of both chemical and electrical components of synaptic transmission.
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