| Project/Area Number |
25640026
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Nagasaki University (2014)
Institute of Physical and Chemical Research (2013) |
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Principal Investigator |
ARUGA Jun 長崎大学, 医歯薬学総合研究科(医学系), 教授 (10232076)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 扁桃体海馬野 / Zic2 / 遺伝子変異マウス / 攻撃行動 / 恐怖記憶 / 扁桃体 / 転写因子 / 遺伝子ターゲッティング / 行動異常 / 神経発生 / 神経回路形成 / タンパク質分解制御 |
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| Outline of Final Research Achievements |
Amygdalohippocampal area (AHA) is located caudally to the amygdalar nuclei, between the amygdala and hippocampus. We found that Zic2 protein is strongly distributed in AHA. We previously showed that Zic2-hypomorphic mutant mice exhibit decreased aggressive behaviors in resident-intruder test and social predominance test. To clarify the role of Zic2 in AHA, we generated Zic2 conditional knockout mice lacking Zic2 in pallium. The mice showed a marked decrement of cell numbers in AHA and an impaired contextual fear memory. We also found that the mice-deficient in Rines, an E3 ubiquitin ligase that degrades Zic2, show reduced aggressive behavior.
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