Clarification of the physiological role of amygdalohippocampal area
Project/Area Number |
25640026
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Nagasaki University (2014) Institute of Physical and Chemical Research (2013) |
Principal Investigator |
ARUGA Jun 長崎大学, 医歯薬学総合研究科(医学系), 教授 (10232076)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 扁桃体海馬野 / Zic2 / 遺伝子変異マウス / 攻撃行動 / 恐怖記憶 / 扁桃体 / 転写因子 / 遺伝子ターゲッティング / 行動異常 / 神経発生 / 神経回路形成 / タンパク質分解制御 |
Outline of Final Research Achievements |
Amygdalohippocampal area (AHA) is located caudally to the amygdalar nuclei, between the amygdala and hippocampus. We found that Zic2 protein is strongly distributed in AHA. We previously showed that Zic2-hypomorphic mutant mice exhibit decreased aggressive behaviors in resident-intruder test and social predominance test. To clarify the role of Zic2 in AHA, we generated Zic2 conditional knockout mice lacking Zic2 in pallium. The mice showed a marked decrement of cell numbers in AHA and an impaired contextual fear memory. We also found that the mice-deficient in Rines, an E3 ubiquitin ligase that degrades Zic2, show reduced aggressive behavior.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.2014
Author(s)
Naoko H. Tomioka, Hiroki Yasuda, Hiroyuki Miyamoto, Minoru Hatayama, Naoko Morimura, Yoshifumi Matsumoto, Toshimitsu Suzuki, Maya Odagawa, Yuri S. Odaka, Yoshimi Iwayama, Ji Won Um, Jaewon Ko, Yushi Inoue, Sunao Kaneko, Shinichi Hirose, Kazuyuki Yamada, Takeo Yoshikawa, Kazuhiro Yamakawa, Jun Aruga
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 45011-16
DOI
Related Report
Peer Reviewed / Open Access
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