The roles of non-coding RNAs on neural differentiaton of human ESCs/iPSCs

• Project/Area Number: 25640038
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Aichi Medical University (2014-2016); Keio University (2013)
• Principal Investigator: Okada Yohei 愛知医科大学, 医学部, 准教授 (30383714)
• Co-Investigator(Renkei-kenkyūsha): MIYA Fuyuki 東京医科歯科大学, 難治疾患研究所, 助教 (50415311)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ヒトES細胞 / ヒトiPS細胞 / ノンコーディングRNA / 神経分化

Outline of Final Research Achievements

Several non-coding RNAs (ncRNAs) upregulated during neural differentiation of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) were identified by genome-wide transcriptome analysis. In addition, methods for the analysis of identified ncRNAs during neural differentiation of human ESCs were also established.

Research Products

• [Journal Article] Altered tau isoform ratio caused by loss of Fus and Sfpq function leads to FTLD-like phenotypes (2017)
  • Author(s): Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G.
  • Journal Title: Cell Reports Volume: 18 Issue: 5 Pages: 1118-1131
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  • Peer Reviewed / Open Access
• [Journal Article] Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy. (2017)
  • Author(s): Nakatsuji H, Araki A, Hashizume A, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Banno H, Suga N, Okada Y, Ohyama M, Nakagawa T, Kishida K, Funahashi T, Shimomura I, Okano H, Katsuno M, Sobue G.
  • Journal Title: J Neurol. Volume: in press Issue: 5 Pages: 839-847
  • DOI: 10.1007/s00415-017-8405-3
  • NAID: 120006331845
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• [Journal Article] Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells. (2016)
  • Author(s): Naoki Ichiyanagi, Koki Fujimori, Masato Yano, Chikako Ishihara-Fujisaki, Takefumi Sone, Tetsuya Akiyama, Yohei Okada, Wado Akamatsu, Takuya Matsumoto, Mitsuru Ishikawa, Yoshinori Nishimoto, Yasuharu Ishihara, Tetsushi Sakuma, Takashi Yamamoto, Hitomi Tsuiji, Naoki Suzuki, Hitoshi Warita, Masashi Aoki, Hideyuki Okano
  • Journal Title: Stem Cell Reports Volume: 6 Issue: 4 Pages: 496-510
  • DOI: 10.1016/j.stemcr.2016.02.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tumour resistance in induced pluripotent stem cells derived from naked mole-rats (2016)
  • Author(s): Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Yoshihiro Tsuchiya, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H & Miura K
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 11471-11471
  • DOI: 10.1038/ncomms11471
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of induced pluripotent stem cells carrying 22q11.2 deletion (2016)
  • Author(s): Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, Iwayama Y, Toyota T, Matsumoto T, Itasaka N, Sugiyama S, Tanaka M, Yano M, Dean B, Okano H, Yoshikawa T
  • Journal Title: Translational Psychiatry Volume: 6 Issue: 11 Pages: e934-e934
  • DOI: 10.1038/tp.2016.206
  • Peer Reviewed / Open Access
• [Journal Article] iPS細胞を用いた認知症モデル (2016)
  • Author(s): 小野寺一成、岡田洋平
  • Journal Title: 最新医学 Volume: 71 Pages: 563-569
• [Journal Article] Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage (2015)
  • Author(s): Andoh-Noda T, Akamatsu W, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H
  • Journal Title: Mol Brain Volume: ８ Issue: 1 Pages: 31-31
  • DOI: 10.1186/s13041-015-0121-2
  • Peer Reviewed / Open Access
• [Journal Article] I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway (2015)
  • Author(s): Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
  • Journal Title: Human Molecular Genetics Volume: 24(17) Issue: 17 Pages: 4879-4900
  • DOI: 10.1093/hmg/ddv212
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism. (2015)
  • Author(s): Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T
  • Journal Title: Sci Rep. Volume: 5 Issue: 1 Pages: 16239-16239
  • DOI: 10.1038/srep16239
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells. (2015)
  • Author(s): Shimojo D, Onodera K, Doi-Torii Y, Ishihara Y, Hattori C, Miwa Y, Tanaka S, Okada R, Ohyama M, Shoji M, Nakanishi A, Doyu M, Okano H, Okada Y
  • Journal Title: Mol Brain Volume: 8 Issue: 1 Pages: 79-93
  • DOI: 10.1186/s13041-015-0172-4
  • Peer Reviewed / Open Access
• [Journal Article] EFA6A, a gunanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth (2015)
  • Author(s): Fukaya M, Fukushima D, Hara Y, Sakagami H.
  • Journal Title: J. Neurochem. Volume: 4 Issue: 3 Pages: 360-73
  • DOI: 10.1016/j.stemcr.2015.01.006
  • Peer Reviewed / Open Access
• [Journal Article] 小児神経疾患克服へ向けた疾患iPS細胞研究の進歩と課題 (2015)
  • Author(s): 沼澤 佑子、岡田洋平、岡野栄之
  • Journal Title: 実験医学増刊号「再生医療2015幹細胞と疾患iPS細胞の最前線」 Volume: 33 Pages: 286-291
• [Journal Article] Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes (2014)
  • Author(s): Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Oasaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
  • Journal Title: Stem Cell Rep Volume: 2 Issue: 5 Pages: 1-14
  • DOI: 10.1016/j.stemcr.2014.03.007
  • Peer Reviewed / Open Access
• [Journal Article] Pathological roles of the VEGF/SphK pathway in Niemann-Pick Type C neurons (2014)
  • Author(s): Lee H, Lee JK , Park. MH, Hong YR, Marti H , Kim H, Okada Y, Otsu M, Seo E, Park J, Bae JH, Okino N, He X, Schuchman E, Bae J, Jin HK
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 5514-5514
  • DOI: 10.1038/ncomms6514
  • Peer Reviewed / Open Access
• [Journal Article] Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses. (2014)
  • Author(s): Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T.
  • Journal Title: Biological Psychiatry Volume: 3223 Issue: 2 Pages: 00570-00578
  • DOI: 10.1016/j.biopsych.2014.07.025
  • NAID: 40020643113
  • Peer Reviewed / Open Access
• [Journal Article] iPS細胞創薬への期待と課題 (2014)
  • Author(s): 岡田洋平、小野寺一成
  • Journal Title: Frontiers in Parkinson Disease Volume: 7 Pages: 204-208
• [Journal Article] Increased l1 retrotransposition in the neuroral genome in schizophrenia. (2014)
  • Author(s): Miki Bundo, Manabu Toyoshima, Yohei Okada, Wado Akamatsu, Junko Ueda, Taeko Nemoto-Miyauchi, Fumiko Sunaga, Michihiro Toritsuka, Daisuke Ikawa, Akiyoshi Kakita, Motoichiro Kato, Kiyoto Kasai, Toshifumi Kishimoto, Hiroyuki Nawa, Hideyuki Okano, Takeo Yoshikawa, Tadafumi Katoemail, Kazuya Iwamoto
  • Journal Title: Neuron Volume: 81 Issue: 2 Pages: 306-313
  • DOI: 10.1016/j.neuron.2013.10.053
  • Peer Reviewed
• [Journal Article] Involvement of Endoplasmic Reticulum Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by Induced-Pluripotent-Stem Cell-Derived Oligodendrocytes (2014)
  • Author(s): Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
  • Journal Title: Stem Cell Report Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy. (2013)
  • Author(s): Nihei Y, Ito D, Okada Y, Akamatsu W, Yagi T, Yoshizaki T, Okano H, Suzuki N.
  • Journal Title: J Biol Chem. Volume: 288 Issue: 12 Pages: 8043-8052
  • DOI: 10.1074/jbc.m112.408211
  • Peer Reviewed
• [Journal Article] A human Dravet syndrome model from patient induced pluripotent stem cells. (2013)
  • Author(s): Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S.
  • Journal Title: Mol Brain Volume: 6 Issue: 1 Pages: 19-19
  • DOI: 10.1186/1756-6606-6-19
  • Peer Reviewed
• [Journal Article] Steps toward safe cell therapy using induced pluripotent stem cells (2013)
  • Author(s): Okano H
  • Journal Title: Circulation Research Volume: 112 Issue: 3 Pages: 523-33
  • DOI: 10.1161/circresaha.111.256149
  • Peer Reviewed
• [Presentation] Reconstruction of Denervated Muscles Using Motor Neurons Derived from Mouse ES Cells (2017)
  • Author(s): Shinkai H., Niwa S., Kurimoto S., Okada Y., Hirata H.
  • Organizer: 2017 annual meeting - Orthopaedic Research Society
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の分子病態の解析 (2017)
  • Author(s): 岡田洋平、小野寺一成、伊藤卓治、下門大祐、道勇学、勝野雅央、祖父江元、岡野栄之
  • Organizer: 新学術領域「脳たんぱく質老化と認知症制御」第５回班員会議
  • Place of Presentation: 名古屋
  • Year and Date: 2017-01-14
• [Presentation] ゲノム編集によるポリグルタミン病の病態解析と治療開発の可能性 (2016)
  • Author(s): 田中智史、伊藤卓治、太田明伸、曽根岳史、今釜史郎、細川好孝、道勇学、岡野栄之、岡田洋平
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-12-02
• [Presentation] ヒトiPS細胞を用いたニューロマスキュラーイメージング (2016)
  • Author(s): 伊藤卓治、田中智史、下門大祐、道勇学、岡野栄之、岡田洋平
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-12-02
• [Presentation] 低酸素培養がヒトiPS細胞由来神経系前駆細胞の分化成熟に与える影響 (2016)
  • Author(s): 李家い;、岡田梨奈、小野寺一成、下門大祐、岡野ジェイムズ洋尚、勝野雅央、道勇、祖父江元、岡野栄之、岡田洋平
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-12-01
• [Presentation] iPS細胞を用いた神経・筋疾患研究 (2016)
  • Author(s): 岡田洋平
  • Organizer: 第３回 筋ジストロフィー研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-10-14
  • Invited
• [Presentation] ヒトiPS細胞を用いたニューロマスキュラーモデルの構築 (2016)
  • Author(s): 田中智史、下門大祐、伊藤卓治、今釜史郎、西田佳弘、道勇学、大野欽司、岡野栄之、石黒直樹、岡田洋平
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-14
• [Presentation] 遺伝性神経筋疾患に対するCRISPR/Cas9によるゲノム編集治療の可能性 (2016)
  • Author(s): 田中智史、伊藤卓治、太田明伸、今釜史郎、西田佳弘、細川好孝、道勇学、大野欽司、石黒直樹、岡田洋平
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-14
• [Presentation] iPS細胞を用いた神経再生と神経疾患研究 (2016)
  • Author(s): 岡田洋平
  • Organizer: 第二回 研究交流会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-10-01
  • Invited
• [Presentation] ゲノム編集によるポリグルタミン病の病態解析と治療開発の可能性 (2016)
  • Author(s): 田中智史、伊藤卓治、太田明伸、曽根岳史、今釜史郎、細川好孝、道勇学、岡野栄之、岡田洋平
  • Organizer: 第1回ゲノム編集学会
  • Place of Presentation: 広島
  • Year and Date: 2016-09-06
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の分子病態の解析 (2016)
  • Author(s): 岡田洋平、小野寺一成、下門大祐、伊藤卓治、道勇学、勝野雅央、祖父江元、岡野栄之
  • Organizer: 新学術領域「脳たんぱく質老化と認知症制御」第４回班員会議
  • Place of Presentation: 千葉
  • Year and Date: 2016-06-04
• [Presentation] Pathophysiological analysis of spinal-bulbar muscular atrophy using disease specific iPSCs (2016)
  • Author(s): Onodera K, Shimojo D, Torii Y, Ishihara Y, Doyu M, Okano H, Katsuno M, Sobue G, Okada Y
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] 疾患特異的ヒトiPS細胞を用いた運動ニューロン疾患の病態解析 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第33回日本神経治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] iPS細胞を用いた神経再生と神経疾患研究 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第21回糖尿病性神経障害を考える会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-24
  • Invited
• [Presentation] iPS細胞を用いた神経疾患研究 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第2回愛知医科大学糖神合同セミナー
  • Place of Presentation: 長久手
  • Year and Date: 2015-10-20
  • Invited
• [Presentation] iPS細胞を用いた神経疾患研究 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: 青森
  • Year and Date: 2015-10-04
  • Invited
• [Presentation] ES細胞、iPS細胞を用いた神経再生と神経疾患研究 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第12回名古屋脊椎脊髄セミナー2015
  • Place of Presentation: 名古屋
  • Year and Date: 2015-07-18
  • Invited
• [Presentation] ヒトiPS細胞の迅速で効率的な神経幹細胞分化誘導法の検討 (2015)
  • Author(s): 安田宗義、小野寺一成、鳥居由紀子、大須賀浩二、道勇 学、高安正和、岡田洋平
  • Organizer: 第30回日本脊髄外科学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-06-25
• [Presentation] 多能性幹細胞（ES細胞、iPS細胞）を用いた神経再生と神経疾患研究 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第3回横浜神経疾患レクチャー
  • Place of Presentation: 横浜
  • Year and Date: 2015-06-11
  • Invited
• [Presentation] ヒト疾患iPS細胞の可能性 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第62回日本実験動物学会総会
  • Place of Presentation: 京都
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] iPS細胞を用いた神経疾患研究 (2015)
  • Author(s): 岡田洋平
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-23
  • Invited
• [Presentation] An approach for understanding the pathogenesis of SBMA by disease specific iPSCs. (2015)
  • Author(s): 小野寺一成、下門大祐、鳥居由紀子、石原康晴、勝野雅央、道勇学、岡野栄之、祖父江元、岡田洋平
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-21
• [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症（SBMA）の病態解析 (2015)
  • Author(s): 小野寺一成、下門大祐、鳥居由紀子、石原康晴、勝野雅央、道勇学、祖父江元、岡野栄之、岡田洋平
  • Organizer: 第14回日本再生医療学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] 疾患特異的iPS細胞を用いたニューロマスキュラーパソロジーの解析 (2015)
  • Author(s): 下門大祐、小野寺一成、石原康晴、勝野雅央、祖父江元、岡野栄之、岡田洋平
  • Organizer: 第14回日本再生医療学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] Pluripotent Stem Cells and Neurological disorders (2014)
  • Author(s): 岡田洋平
  • Organizer: Distinctive educational program 2014 Neuroscience Course
  • Place of Presentation: 名古屋
  • Year and Date: 2014-12-10
  • Invited
• [Presentation] iPS細胞を用いた神経疾患研究 (2014)
  • Author(s): 岡田洋平
  • Organizer: 日本神経学会中国四国地方会
  • Place of Presentation: 広島
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] Dysmyelination and Enhanced ER Stress Response in Pelizaeus-Merzbacher Disease Patients iPSCs-Derived Oligodendrocytes with PLP1 Gene Missense Mutations. (2014)
  • Author(s): Numasawa Y, Okada Y, Shibata S, Kawabata S, Nakamura M, Kishi N, Akamatsu W, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H,
  • Organizer: Neuroscience 2014
  • Place of Presentation: 浜松
  • Year and Date: 2014-11-15 – 2014-11-19
  • Invited
• [Presentation] iPS細胞を用いた神経疾患研究 (2014)
  • Author(s): 岡田洋平
  • Organizer: 新潟パーキンソン病治療研究会
  • Place of Presentation: 新潟
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] Application of pluripotent stem cells to the research on neurological disorders (2014)
  • Author(s): Okada Y
  • Organizer: 2014 KALAS international symposium
  • Place of Presentation: Yeosu, Korea
  • Year and Date: 2014-08-21 – 2014-08-23
  • Invited
• [Presentation] 多能性幹細胞（ES細胞・iPS細胞）を用いた神経再生とその問題点 (2014)
  • Author(s): 岡田洋平
  • Organizer: 第3回長久手脊椎脊髄セミナー
  • Place of Presentation: 長久手
  • Year and Date: 2014-07-31
  • Invited
• [Presentation] 白質ジストロフィーの病態研究と問題点 (2014)
  • Author(s): 沼澤佑子、岡田洋平、芝田晋介、川端走野、中村雅也、岸憲幸、赤松和土、大山学、小坂仁 、井上健、高橋和利、山中伸弥、小崎健次郎、高橋孝雄、岡野栄之
  • Organizer: 第56回小児神経学会学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2014-05-29 – 2014-05-31
  • Invited
• [Presentation] Incompletely reprogrammed human iPSCs form glioma-like tumors through genomic instability during differentiation (2014)
  • Author(s): Okada Y
  • Organizer: Kyoto University/Keio Universiy/MD Anderson Cancer Center (MDACC) Joint Conference, iPS and Stem Cells in Cancer Research
  • Place of Presentation: 京都
  • Year and Date: 2014-04-17
  • Invited
• [Presentation] Incompletely reprogrammed human iPSCs form glioma-like tumors through genomic instability during neural differentiation
  • Author(s): Okada Y, Miya, F, Koike M, Tomisato S, Tokura T, Ishihara Y, Shimojo D, Hattori C, Kanematsu D, Kanemura Y, Kohda K, Sobue G, Yamanaka S, Yuzaki M, Uchiyama Y, Ikeda E, Tsunoda T, Okano H,
  • Organizer: The 11th Stem Cell Research Symposium
  • Place of Presentation: Tokyo
  • Invited
• [Presentation] 不完全にリプログラミングされたヒトiPS細胞は分化誘導に伴うゲノム不安定化を通してグリオーマ様腫瘍を形成する
  • Author(s): 岡田洋平、宮冬樹、小池正人、冨里周太、戸倉智子、石原康晴、下門大祐、服部千夏、兼松大介、金村米博、幸田和久、祖父江元、山中伸弥、柚崎通介、内山安男、池田栄二、角田達彦、岡野栄之
  • Organizer: 第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会
  • Place of Presentation: 京都
• [Presentation] 多能性幹細胞(ES細胞/iPS細胞)の神経分化誘導とその応用
  • Author(s): 岡田洋平
  • Organizer: 第35回神経組織培養研究会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 培養皿の上で神経を作る―多能性幹細胞（ES細胞・iPS細胞）を用いた神経発生、神経再生、病態解析研究
  • Author(s): 岡田洋平
  • Organizer: 愛知医科大学先端医学研究センター 第13回研究セミナー
  • Place of Presentation: 愛知
  • Invited
• [Presentation] 多能性幹細胞を用いた神経疾患研究
  • Author(s): 岡田洋平
  • Organizer: ハンドフロンティア 第89回 前向き研究会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] iPS細胞を用いた神経疾患研究
  • Author(s): 岡田洋平
  • Organizer: 愛知医科大学加齢医科学研究所30周年記念講演会
  • Place of Presentation: 愛知
  • Invited
• [Book] アクチュアル脳・神経疾患の臨床「神経疾患治療ストラテジー」 (2017)
  • Author(s): 伊藤卓治、岡田洋平
  • Publisher: 中山書店
• [Book] 再生医療用語ハンドブック (2015)
  • Author(s): 下門大祐、岡田洋平
  • Total Pages: 336
  • Publisher: 株式会社メディカルトリビューン
• [Book] 実験医学別冊「ES・iPS細胞実験スタンダード」 (2014)
  • Author(s): 岡田洋平、岡野栄之
  • Total Pages: 355
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html