Development of novel therapy using artificial super cancer cells

• Project/Area Number: 25640070
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Tokai University
• Principal Investigator: KOTANI Ai 東海大学, 医学部, 准教授 (00517477)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 腫瘍 / がん / クローナルドミナンス

Outline of Final Research Achievements

The clonal competition between tumor clones has been reported.In this study, we tried to apply it to the novel cancer therapy.
First we established the model system for studying it. Next the mechanism of the phenomenon was investigated.We found that the phenomenon seemed prominent in the mouse model mediated by the soluble factor.Then we tried to identify the factor; several candidate molecules were studied.now.

Research Products

• [Journal Article] Novel functional small RNAs are selectively loaded onto mammalian Ago1 (2014)
  • Author(s): Yamakawa, N. Okuyama, K. Ogata, J. Kanai, A. Helwak, A. Takamatsu, M. Imadome, K. I. Takakura, K. Chanda, B. Kurosaki, N. Yamamoto, H. Ando, K. Matsui, H. Inaba, T. Kotani, A.
  • Journal Title: Nucleic Acids Res Volume: 未確定 Issue: 8 Pages: 5289-5301
  • DOI: 10.1093/nar/gku137
  • Peer Reviewed / Open Access
• [Journal Article] Small RNA as a regulator of hematopoietic development, immune response in infection and tumorigenesis (2014)
  • Author(s): Okuyama K, Ogata J, Yamakawa N, Chanda B, Kotani A.
  • Journal Title: International Journal of Hematology Volume: 99 Issue: 5 Pages: 553-60
  • DOI: 10.1007/s12185-014-1564-4
  • Peer Reviewed
• [Journal Article] Guest editorial :noncoding RNA in RNA hematopoietic system (2014)
  • Author(s): Kotani A
  • Journal Title: International Journal of Hematology Volume: 99 Issue: 5 Pages: 529-30
  • DOI: 10.1007/s12185-014-1574-2
  • Peer Reviewed
• [Journal Article] Genomic mutator Activation-induced cytidine deaminase (AID) as a therapeutic target (2014)
  • Author(s): Kotani A
  • Journal Title: Rinsho Ketsueki Volume: 55 Issue: 7 Pages: 780-784
  • DOI: 10.11406/rinketsu.55.780
  • NAID: 130004678954
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] The role of tumor-derived secretary small RNAs in EBV related lymphoma (2014)
  • Author(s): Kotani A
  • Journal Title: Uirusu Volume: 64 Issue: 1 Pages: 43-48
  • DOI: 10.2222/jsv.64.43
  • NAID: 130004922977
  • ISSN: 0042-6857, 1884-3433
  • Peer Reviewed
• [Journal Article] Novel functional small RNAs are selectively loaded onto mammalian Ago1. (2014)
  • Author(s): Yamakawa N, Okuyama K, Ogata J, Kanai A, Helwak A, Takamatsu M, Imadome KI, Takakura K, Chanda B, Kurosaki N, Yamamoto H, Ando K, Matsui H, Inaba T, Kotani A.
  • Journal Title: Nucleic Acids Res Volume: in press
  • Peer Reviewed
• [Journal Article] Guest editorial: noncoding RNA in hematopoietic system. (2014)
  • Author(s): Ai Kotani
  • Journal Title: IJH Volume: in press
  • Peer Reviewed
• [Journal Article] Small RNA as a regulator of hematopoietic development, immune response in infection and tumorigenesis. (2014)
  • Author(s): Okuyama K, Ogata J, Yamakawa N, Chanda B, Kotani A.
  • Journal Title: IJH Volume: in press
  • Peer Reviewed
• [Journal Article] miR-126-mediated control of cell fate in B cell-myeloid progenitors as a potential (2013)
  • Author(s): 1．Kazuki Okuyama, Tomokatsu Ikawa, Bernhard Gentner, Katsuto Hozumi,
  • Journal Title: PNAS Volume: 110 Pages: 13410-5
  • Peer Reviewed
• [Journal Article] In vivo leukemogenic potential of an interleukin 7 receptor α chain mutant in hematopoietic stem and progenitor cells. (2013)
  • Author(s): Yokoyama K, Yokoyama N, Izawa K, Kotani A, Harashima A, Hozumi K, Tojo A.
  • Journal Title: BLOOD Volume: 122 Pages: 4259-63
  • Peer Reviewed
• [Presentation] single micro-RNA can completely rescue B-cell differentiation arrest due to EBF1 deficiency (2014)
  • Author(s): Bidisha, Chanda, Tomokatsu Ikawa, Kazuki Okuyama, Katsuto Hozumi, Hiroshi Kawamoto, Ai Kotani
  • Organizer: Cold Spring Harber Laboratory Meeting
  • Place of Presentation: New York
• [Presentation] miRNAは転写因子を超えられるか (2013)
  • Author(s): 幸谷 愛
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] ＥＢＶ関連リンパ腫から放出される分泌性ＥＢＶコード小分子ＲＮＡの炎症性ニッチ形成における役割 (2013)
  • Author(s): 幸谷 愛
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 治療標的としてのAID (2013)
  • Author(s): 幸谷 愛
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] がん細胞の分泌する細胞顆粒とマイクロRNA "腫瘍由来分泌性小分子RNAによる炎症性ニッチの制御 (2013)
  • Author(s): 幸谷 愛
  • Organizer: 第72回日本癌学会学術総会 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Invited
• [Remarks] 幸谷研究室
  • URL: http://kotani.med.u-tokai.ac.jp/
• [Remarks] 幸谷研究室
  • URL: http://kotani.med.u-tokai.ac.jp/